N-(3-甲氧基-4-硝基苯基)乙酰胺合成路线 （共 11 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 2 h;
参考文献
Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
Location in patent: Page/Page column 78 ;
US 20120015962 A1
反应条件
nitric acid in acetic acid T=0 - 20°C;
参考文献
Egris, Riccardo; Villacampa, Mercedes; Carlos Menendez
Chemistry - A European Journal, 2009 , vol. 15, # 41 p. 10930 - 10939
反应条件
nitric acid; acetic anhydride
参考文献
Leclerc; Marciniak; Decker; Schwartz
Journal of Medicinal Chemistry, 1986 , vol. 29, # 12 p. 2433 - 2438
反应条件
1: pyridine / 4-(N,N-dimethlyamino)pyridine / 62 h / 0 - 20 °C 2: nitric acid / 3 h / -15 - -10 °C 3: potassium carbonate / methanol / 3 h / 20 °C 4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme
参考文献
Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
US 20120015962 A1
反应条件
1: 86 percent / 1 h / Heating 2: 20 percent / HNO3, Ac2O View Scheme
参考文献
Suzuki, Hitomi; Tatsumi, Atsuo; Ishibashi, Taro; Mori, Tadashi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 4 p. 339 - 344
反应条件
1: nitric acid / 3 h / -15 - -10 °C 2: potassium carbonate / methanol / 3 h / 20 °C 3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme
参考文献
Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
US 20120015962 A1
反应条件
1: potassium carbonate / methanol / 3 h / 20 °C 2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme
参考文献
Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
US 20120015962 A1
反应条件
bei der Nitrierung; Produkt 5: 2.6-Dinitro-3-acetamino-anisol; Produkt 6: 4.6-Dinitro-3-acetamino-anisol;
参考文献
Meldola; Stephens
Journal of the Chemical Society, 1906 , vol. 89, p. 924
Full Text Show Details
Reverdin; Widmer
Chemische Berichte, 1913 , vol. 46, p. 4074
反应条件
1: 4N aq. HCl / ethanol / 3 h / Heating 2: pyridine / 4 h / 20 °C 3: H2 / Pd/C / methanol / 0.25 h / 1520 Torr View Scheme
参考文献
Atwell, Graham J.; Rewcastle, Gordon W.; Baguley, Bruce C.; Denny, William A.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 652 - 658
反应条件
1: 4N aq. HCl / ethanol / 3 h / Heating 2: pyridine / 4 h / 20 °C 3: H2 / Pd/C / methanol / 0.25 h / 1520 Torr 4: HCl / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 4 p. 652 - 658
