1-(2-甲氧基-5-甲基苯基)乙酮合成路线 （共 17 条）
反应条件
AlCl3, aluminium chloride in dichloromethane T=-5 - 25°C;
参考文献
Du, Zhen-Ting; Lu, Jing; Yu, Hong-Rui; Xu, Yan; Li, An-Pai
Journal of Chemical Research, 2010 , # 4 p. 222 - 227
反应条件
AlCl3, aluminium chloride in dichloromethane
T=0 - 20°C; 3 h;
参考文献
JUBILANT BIOSYS LTD.; SARMA, Pakala Kumara Savithru; ACHARYA, Vinod Parameshwaran; KASIBHATLA, Srinivas Rao; VISWANADHAN, Vellarkad Narayana; TIWARI, Atul; SINGHA, Rakesh Kumar; BISCHOFF, Alexander
Patent: WO2012/90219 A2, 2012 ;
Location in patent: Page/Page column 86 ;
反应条件
aluminium dodecatungstophosphate; trifluoroacetic anhydride
T=20°C; Friedel-Crafts acylation; 2 h;
参考文献
Khodaei, Mohammd Mehdi; Alizadeh, Abdolhamid; Nazari, Ehsan
Tetrahedron Letters, 2007 , vol. 48, # 24 p. 4199 - 4202
反应条件
lithium perchlorate
T=100°C; 3 h;
参考文献
Bartoli, Giuseppe; Bosco, Marcella; Marcantoni, Enrico; Massaccesi, Massimo; Rinaldi, Samuele; Sambri, Letizia
Tetrahedron Letters, 2002 , vol. 43, # 36 p. 6331 - 6333
反应条件
potassium carbonate in N,N-dimethyl-formamide
18 h; Ambient temperature;
参考文献
Buckle, Derek, R.; Rockell, Caroline J. M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2443 - 2446
反应条件
1: tetrakis(triphenylphosphine) palladium(0); triethylamine; copper(I) bromide / toluene / 5 h / 20 °C / |Inert atmosphere; |Schlenk technique
2: potassium carbonate / methanol / 4 h / 20 °C
3: tetrakis(triphenylphosphine) palladium(0); hydrogenchloride / tetrahydrofuran; water / 168 h / 45 °C / |Inert atmosphere; |Schlenk technique
View Scheme
参考文献
Xu, Caixia; Du, Weiyuan; Zeng, Yi; Dai, Bin; Guo, Hao
Organic Letters, 2014 , vol. 16, # 3 p. 948 - 951
反应条件
PPA
beim Acetylieren;
参考文献
Horton; Spence
Journal of the American Chemical Society, 1958 , vol. 80, p. 2453,2456
反应条件
carbon disulfide; aluminium trichloride
参考文献
Noller; Adams
Journal of the American Chemical Society, 1924 , vol. 46, p. 1892
反应条件
sodium perchlorate; acetic acid
参考文献
Mathur et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 3582,3585
反应条件
hydrogenchloride; n-butyllithium; bis(cyclopentadienyl)zirconium monomethylmonochloride
1.) THF, hexane, -50 deg C, 30 min, 2.) THF, -50 deg C, 15 min, 3.) THF, 80 deg C, 24 h, room temperature, 4 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Buchwald,S.; Watson,B.T.; Lum,R.T.
Journal of the American Chemical Society, 1987 , vol. 109, p. 7137
