[2-羟基-1-(4-甲基-2,6,7-三氧杂双环[2.2.2]辛-1-基)丙基]氨基甲酸苄酯合成路线 （共 5 条）
反应条件
1: in diethyl ether; dichloromethane T=-78°C; 0.025 h; Inert atmosphereCooling with ice; 2: With ammonium chloride in diethyl ether; dichloromethane 0.25 h;
参考文献
Liang, Xiaofei; Lee, Chul-Jin; Zhao, Jinshi; Toone, Eric J.; Zhou, Pei
Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6954 - 6966
反应条件
1: 92 percent / NaBr / acetone / 30 h / Heating 2: 1.) Cs2CO3 / 1.) H2O, 20 min, 2.) DMF, room temperature, 24 h 3: 1.) BF3*Et2O, 2.) TEA / 1.) CH2Cl2, 0 deg C to room temperature, 6 h, 2.) 30 min View Scheme
参考文献
Liang, Xiaofei; Lee, Chul-Jin; Zhao, Jinshi; Toone, Eric J.; Zhou, Pei
Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6954 - 6966
反应条件
TEA; boron trifluoride diethyl etherate 1.) CH2Cl2, 0 deg C to room temperature, 6 h, 2.) 30 min; Yield given. Multistep reaction;
参考文献
Blaskovich, Mark A.; Evindar, Ghotas; Rose, Nicholas G. W.; Wilkinson, Scott; Luo, Yue; Lajoie, Gilles A.
Journal of Organic Chemistry, 1998 , vol. 63, # 11 p. 3631 - 3646
反应条件
1: 1.) Cs2CO3 / 1.) H2O, 20 min, 2.) DMF, room temperature, 24 h 2: 1.) BF3*Et2O, 2.) TEA / 1.) CH2Cl2, 0 deg C to room temperature, 6 h, 2.) 30 min View Scheme
参考文献
Blaskovich, Mark A.; Evindar, Ghotas; Rose, Nicholas G. W.; Wilkinson, Scott; Luo, Yue; Lajoie, Gilles A.
Journal of Organic Chemistry, 1998 , vol. 63, # 11 p. 3631 - 3646
反应条件
1: 1.) Cs2CO3 / 1.) H2O, 20 min, 2.) DMF, room temperature, 24 h 2: 1.) BF3*Et2O, 2.) TEA / 1.) CH2Cl2, 0 deg C to room temperature, 6 h, 2.) 30 min View Scheme
参考文献
Blaskovich, Mark A.; Evindar, Ghotas; Rose, Nicholas G. W.; Wilkinson, Scott; Luo, Yue; Lajoie, Gilles A.
Journal of Organic Chemistry, 1998 , vol. 63, # 11 p. 3631 - 3646
