2-吡啶基-alpha-苄基甲醇合成路线 （共 10 条）
反应条件
phenyllithium in tetrahydrofuran T=-78 - 20°C;
参考文献
Huang, Yao-Zeng; Liao, Yi
Journal of Organic Chemistry, 1991 , vol. 56, # 4 p. 1381 - 1386
反应条件
1: 2-bromo-pyridine With isopropylmagnesium chloride in tetrahydrofuran T=20°C; Substitution; 2 h; 2: phenylacetaldehyde in tetrahydrofuran T=20°C; Substitution; 18 h;
参考文献
Trecourt, Francois; Breton, Gilles; Bonnet, Veronique; Mongin, Florence; Marsais, Francis; Queguiner, Guy
Tetrahedron, 2000 , vol. 56, # 10 p. 1349 - 1360
反应条件
in tetrahydrofuran; diethyl ether T=0°C; 2 h;
参考文献
Li, Ang; Kindelin, Patrick J.; Klumpp, Douglas A.
Organic Letters, 2006 , vol. 8, # 6 p. 1233 - 1236
参考文献
Sperber et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 887,889
反应条件
sodium amide; xylene
参考文献
Suzuki
Pharmaceutical Bulletin, 1956 , vol. 4, p. 211,212,214
参考文献
Raeth
Chemische Berichte, 1924 , vol. 57, p. 841
反应条件
1: 76 percent / Ambient temperature 2: 1) BuLi / 1) THF, hexane, -70 deg C, 30 min, 2) -70 deg C to room temperature View Scheme
参考文献
Li, Sao-Wei; Zhou, Zhang-Lin; Huang, Yao-Zeng; Shi, Li-Lan
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 5 p. 1099 - 1100
反应条件
1: benzyl alcohol 2: xylene; sodium amide View Scheme
参考文献
Suzuki
Pharmaceutical Bulletin, 1956 , vol. 4, p. 211,212,214
反应条件
n-butyllithium 1) THF, hexane, -70 deg C, 30 min, 2) -70 deg C to room temperature; Yield given. Multistep reaction;
参考文献
Li, Sao-Wei; Zhou, Zhang-Lin; Huang, Yao-Zeng; Shi, Li-Lan
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 5 p. 1099 - 1100
反应条件
Sodium bromate; CeEPS10 in acetonitrile
48 h; Heating;
参考文献
Al-Haq, Nazli; Sullivan, Alice C.; Wilson, John R. H.
Tetrahedron Letters, 2003 , vol. 44, # 4 p. 769 - 771
