2-硝基-5-甲基苯甲酸甲酯合成路线 （共 15 条）
反应条件
sulfuric acid in methanol 48 h; Heating / reflux;
参考文献
US2004/214798 A1, ;
Page 17 ;
反应条件
hydrogenchloride 20 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 21, p. 1807 - 1816
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 4 h;
参考文献
EP2103601 A1, ;
Page/Page column 35 ;
反应条件
1: fuming nitric acid 2: HCl View Scheme
参考文献
Chemische Berichte, , vol. 42, p. 433
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 20, p. 162
反应条件
1: aqueous methanol. hydrochloric acid; tin 2: aqueous hydrochloric acid; copper (II)-sulfate; water / Diazotization.Erhitzen des Reaktionsgemisches 3: aqueous hydrochloric acid View Scheme
参考文献
Hayashi
Journal of the Chemical Society, 1930 , p. 1513,1516
反应条件
chromium(VI) oxide; periodic acid in acetonitrile T=20°C;
参考文献
NEUROTUNE AG; AHMED, Shaheen; HETTWER, Stefan; VRIJBLOED, Jan Willem; FARINA, Carlo; ALLGEIER, Hans
Patent: WO2012/59442 A2, 2012 ;
Location in patent: Page/Page column 57 ;
WO 2012/059442 A2
反应条件
sulfuric acid; acetic acid in dichloromethane; acetic anhydride
参考文献
Janssen Pharmaceutica N.V.
Patent: US5043327 A1, 1991 ;
反应条件
hydrogenchloride; tin
参考文献
Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4416 - 4420
反应条件
1: 60 percent / NBS, benzoylperoxide / CCl4 / 5 h / Heating; Irradiation
2: 40 percent / 0.2 N NaOH / methanol / Ambient temperature
3: 90 percent / H2 / PtO2, 80percent / methanol / 20 h / 25 °C / 735.5 Torr
4: 50 percent / 2,6-lutidine / benzene
5: 65 percent / NaH / dimethylformamide; CH2Cl2 / Ambient temperature
6: water, 0.1 N NaOH / pyridine; methanol / 24 h / Heating
View Scheme
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
