Novozym 435 T=50°C; 16 h; Polyacrylate;

hydrogenchloride; water in ethanol T=20°C; 18 h; Inert atmosphere;

novozyme 435 T=25°C; 45 h;

1: thionyl chloride / 1 h / 60 °C 2: pyridine / 18 h / Inert atmosphere 3: hydrogenchloride; water / ethanol / 18 h / 20 °C / Inert atmosphere View Scheme

1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 48 h / 20 °C / Cooling with ice; Inert atmosphere 2: pyridine / 18 h / Inert atmosphere 3: hydrogenchloride; water / ethanol / 18 h / 20 °C / Inert atmosphere View Scheme

1: pyridine / 24 h / 20 °C / Inert atmosphere 2: diisobutylaluminium hydride / tetrahydrofuran; toluene / 48 h / 20 °C / Cooling with ice; Inert atmosphere 3: pyridine / 18 h / Inert atmosphere 4: hydrogenchloride; water / ethanol / 18 h / 20 °C / Inert atmosphere View Scheme

1: nitric acid; sodium nitrite / water / 1.5 h / 70 °C / Inert atmosphere 2: thionyl chloride / 1 h / 60 °C 3: pyridine / 18 h / Inert atmosphere 4: hydrogenchloride; water / ethanol / 18 h / 20 °C / Inert atmosphere View Scheme

1: pyridine / 18 h / Inert atmosphere 2: hydrogenchloride; water / ethanol / 18 h / 20 °C / Inert atmosphere View Scheme