乙基[6-(甲基氨基)-2-吡啶基]乙酸酯合成路线 （共 4 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 16 h;
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 4 p. 926 - 934
反应条件
1.1: 16 h / 60 °C 2.1: NaH / dimethylformamide / 1.25 h / 0 - 20 °C 2.2: 7.56 g / dimethylformamide / 16 h / 20 °C 3.1: lithium diisopropylamide / tetrahydrofuran / 0.25 h / -78 °C 3.2: 60 percent / tetrahydrofuran / 2.25 h / -78 - 0 °C 4.1: 100 percent / CF3CO2H / CH2Cl2 / 16 h / 20 °C View Scheme
参考文献
Marugan, Juan Jose; Manthey, Carl; Anaclerio, Beth; Lafrance, Lou; Lu, Tianbao; Markotan, Tom; Leonard, Kristi A.; Crysler, Carl; Eisennagel, Stephen; Dasgupta, Malini; Tomczuk, Bruce
Journal of Medicinal Chemistry, 2005 , vol. 48, # 4 p. 926 - 934
反应条件
1.1: NaH / dimethylformamide / 1.25 h / 0 - 20 °C 1.2: 7.56 g / dimethylformamide / 16 h / 20 °C 2.1: lithium diisopropylamide / tetrahydrofuran / 0.25 h / -78 °C 2.2: 60 percent / tetrahydrofuran / 2.25 h / -78 - 0 °C 3.1: 100 percent / CF3CO2H / CH2Cl2 / 16 h / 20 °C View Scheme
参考文献
Marugan, Juan Jose; Manthey, Carl; Anaclerio, Beth; Lafrance, Lou; Lu, Tianbao; Markotan, Tom; Leonard, Kristi A.; Crysler, Carl; Eisennagel, Stephen; Dasgupta, Malini; Tomczuk, Bruce
Journal of Medicinal Chemistry, 2005 , vol. 48, # 4 p. 926 - 934
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran / 0.25 h / -78 °C 1.2: 60 percent / tetrahydrofuran / 2.25 h / -78 - 0 °C 2.1: 100 percent / CF3CO2H / CH2Cl2 / 16 h / 20 °C View Scheme
参考文献
Marugan, Juan Jose; Manthey, Carl; Anaclerio, Beth; Lafrance, Lou; Lu, Tianbao; Markotan, Tom; Leonard, Kristi A.; Crysler, Carl; Eisennagel, Stephen; Dasgupta, Malini; Tomczuk, Bruce
Journal of Medicinal Chemistry, 2005 , vol. 48, # 4 p. 926 - 934
