3-氨基-5-(三氟甲基)苯甲酰胺合成路线 （共 4 条）
反应条件
palladium monocarbide in tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide
参考文献
Signal Pharmaceuticals, Inc.
Patent: US5811428 A1, 1998 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol
18 h;
参考文献
Sullivan, Robert W.; Bigam, Colin G.; Erdman, Paul E.; Palanki, Moorthy S. S.; Anderson, David W.; Goldman, Mark E.; Ransone, Lynn J.; Suto, Mark J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 413 - 419
反应条件
1: NH4OH / tetrahydrofuran / 18 h
2: H2 / 5percent Pd/C / ethanol / 18 h
View Scheme
参考文献
Sullivan, Robert W.; Bigam, Colin G.; Erdman, Paul E.; Palanki, Moorthy S. S.; Anderson, David W.; Goldman, Mark E.; Ransone, Lynn J.; Suto, Mark J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 413 - 419
反应条件
1: (COCl)2, DMF / CH2Cl2 / 18 h
2: NH4OH / tetrahydrofuran / 18 h
3: H2 / 5percent Pd/C / ethanol / 18 h
View Scheme
参考文献
Sullivan, Robert W.; Bigam, Colin G.; Erdman, Paul E.; Palanki, Moorthy S. S.; Anderson, David W.; Goldman, Mark E.; Ransone, Lynn J.; Suto, Mark J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 413 - 419
