7-苄氧基-6-甲氧基-1H-喹啉-4-酮合成路线 （共 7 条）
反应条件
1: 2-amino-4-benzyloxy-5-methoxyacetophenone With sodium methylate in ethylene glycol dimethyl ether T=0°C; 1 h; 2: formic acid ethyl ester in ethylene glycol dimethyl ether T=0 - 20°C;
参考文献
MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E.V.; ULLRICH, Axel; TORKA, Robert; ZHANG, Yixiang; KERI, Gyoergy; OeRFI, Laszlo; SZABADKAI, Istvan
Patent: WO2011/45084 A1, 2011 ;
Location in patent: Page/Page column 49; 50 ;
WO 2011/045084 A1
反应条件
in diphenylether 0.0833333 h; Heating / reflux;
参考文献
Zeneca Limited; Zeneca Pharma S.A.
Patent: US6809097 B1, 2004 ;
Location in patent: Page column 40 ;
US 6809097 B1
反应条件
1.1: potassium carbonate / potassium iodide / acetone / 48 h / Reflux 2.1: nitric acid; acetic acid / 18 h / 10 - 20 °C 3.1: zinc; ammonium chloride / ethanol; water / 5 h / Reflux 4.1: sodium methylate / ethylene glycol dimethyl ether / 1 h / 0 °C 4.2: 0 - 20 °C View Scheme
参考文献
MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E.V.; ULLRICH, Axel; TORKA, Robert; ZHANG, Yixiang; KERI, Gyoergy; OeRFI, Laszlo; SZABADKAI, Istvan
Patent: WO2011/45084 A1, 2011 ;
WO 2011/045084 A1
反应条件
1.1: potassium carbonate / potassium iodide / acetone / 48 h / Reflux 2.1: nitric acid; acetic acid / 18 h / 10 - 20 °C 3.1: zinc; ammonium chloride / ethanol; water / 5 h / Reflux 4.1: sodium methylate / ethylene glycol dimethyl ether / 1 h / 0 °C 4.2: 0 - 20 °C View Scheme
参考文献
MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E.V.; ULLRICH, Axel; TORKA, Robert; ZHANG, Yixiang; KERI, Gyoergy; OeRFI, Laszlo; SZABADKAI, Istvan
Patent: WO2011/45084 A1, 2011 ;
WO 2011/045084 A1
反应条件
1.1: nitric acid; acetic acid / 18 h / 10 - 20 °C 2.1: zinc; ammonium chloride / ethanol; water / 5 h / Reflux 3.1: sodium methylate / ethylene glycol dimethyl ether / 1 h / 0 °C 3.2: 0 - 20 °C View Scheme
参考文献
MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E.V.; ULLRICH, Axel; TORKA, Robert; ZHANG, Yixiang; KERI, Gyoergy; OeRFI, Laszlo; SZABADKAI, Istvan
Patent: WO2011/45084 A1, 2011 ;
WO 2011/045084 A1
反应条件
1.1: zinc; ammonium chloride / ethanol; water / 5 h / Reflux 2.1: sodium methylate / ethylene glycol dimethyl ether / 1 h / 0 °C 2.2: 0 - 20 °C View Scheme
参考文献
MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E.V.; ULLRICH, Axel; TORKA, Robert; ZHANG, Yixiang; KERI, Gyoergy; OeRFI, Laszlo; SZABADKAI, Istvan
Patent: WO2011/45084 A1, 2011 ;
WO 2011/045084 A1
反应条件
trichlorophosphate 2 h; Heating / reflux;
参考文献
WO2005/30140 A2, ;
Page/Page column 199 ;
WO 2005/030140 A2
