5-甲氧基苯并[b]噻吩合成路线 （共 31 条）
反应条件
1: 1.) PIFA, BF3*Et2O, 2.) MeNH2 / 1.) CH2Cl2, -78 deg C, 30 min, 2.) CH2Cl2, H2O, r.t., 30 min 2: 88 percent / N-chlorosuccinimide View Scheme
参考文献
Synthesis, , # 5 p. 885 - 897
反应条件
1: aqueous sulfuric acid; sodium nitrite / aus Diazoniumsalz-Loesung 2: alkaline solution View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 527, p. 83,101
反应条件
1: lead (II)-oxide / 480 °C 2: aqueous sulfuric acid; sodium nitrite / aus Diazoniumsalz-Loesung 3: alkaline solution View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 527, p. 83,101
反应条件
1: iron (II)-sulfate; aqueous ammonia 2: lead (II)-oxide / 480 °C 3: aqueous sulfuric acid; sodium nitrite / aus Diazoniumsalz-Loesung 4: alkaline solution View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 527, p. 83,101
反应条件
1: Na2S; Na2CO3; aqueous ethanol / Erhitzen der Reaktionsloesung mit wss.Natrium-chloracetat-Loesung 2: aq. NaOH solution 3: iron (II)-sulfate; aqueous ammonia 4: lead (II)-oxide / 480 °C 5: aqueous sulfuric acid; sodium nitrite / aus Diazoniumsalz-Loesung 6: alkaline solution View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 527, p. 83,101
反应条件
1: aq. NaOH solution 2: iron (II)-sulfate; aqueous ammonia 3: lead (II)-oxide / 480 °C 4: aqueous sulfuric acid; sodium nitrite / aus Diazoniumsalz-Loesung 5: alkaline solution View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 527, p. 83,101
反应条件
1: ethanol; sodium disulfide / anschliessend Erwaermen mit Natriumsulfid und wss. Natronlauge und Erwaermen des Reaktionsgemisches mit Natrium-chloracetat in Wasser 2: iron (II)-sulfate; aqueous ammonia 3: lead (II)-oxide / 480 °C 4: aqueous sulfuric acid; sodium nitrite / aus Diazoniumsalz-Loesung 5: alkaline solution View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 527, p. 83,101
参考文献
Justus Liebigs Annalen der Chemie, , vol. 527, p. 83,101
反应条件
BBr3*Me2S complex in chlorobenzene 8 h; Reflux;
参考文献
Chiummiento, Lucia; Funicello, Maria; Lupattelli, Paolo; Tramutola, Francesco; Berti, Federico; Marino-Merlo, Francesca
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2948 - 2950
反应条件
1: With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran T=-40 - -30°C; 1.25 h; 2: With boric acid trimethyl ester in tetrahydrofuran T=-30 - 20°C; 3: With hydrogenchloride in tetrahydrofuran; water
参考文献
Molino, Bruce F.; Liu, Shuang; Guzzo, Peter R.; Beck, James P.
Patent: US2006/52378 A1, 2006 ;
Location in patent: Page/Page column 102 ;
US 20060052378 A1
