5-甲氧基苯并[b]噻吩合成路线 （共 31 条）
反应条件
PPA in chlorobenzene 24 h; Heating;
参考文献
Perez-Silanes; Martinez-Esparza; Oficialdegui; Villanueva; Orus; Monge
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 5 p. 1025 - 1030
反应条件
PPA in chlorobenzene Heating / reflux;
参考文献
CHUGAI SEIYAKU KABUSHIKI KAISHA
Patent: EP1803721 A1, 2007 ;
Location in patent: Page/Page column 22 ;
反应条件
t-Bu Brett Phos; C44H62NO5PPdS; sodium t-butanolate in 1,4-dioxane T=80°C; 20 h; Sealed tubeInert atmosphere;
参考文献
Cheung, Chi Wai; Buchwald, Stephen L.
Organic Letters, 2013 , vol. 15, # 15 p. 3998 - 4001
反应条件
1: With copper(I) bromide in methanol 1 h; Reflux; 2: With copper in methanol T=20°C; 144 h; Reflux; Product distribution / selectivity;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/5998 A1, 2009 ;
Location in patent: Page/Page column 248-249 ;
反应条件
quinoline; copper T=190°C; 1.5 h;
参考文献
US2010/279983 A1, ;
Page/Page column 23 ;
US 20100279983 A1
反应条件
potassium carbonate in acetone T=0°C; 2 h;
参考文献
Misra; Ganguly; Kamila; Basu; De
Spectrochimica Acta - Part A Molecular and Biomolecular Spectroscopy, 2001 , vol. 57, # 14 p. 2795 - 2808
反应条件
sodium hydroxide; sodium tetrahydroborate in methanol; water 13 h; Heating;
参考文献
Mukherjee, Chandrani; Kamila, Sukanta; De, Asish
Tetrahedron, 2003 , vol. 59, # 26 p. 4767 - 4774
反应条件
sodium methylate; copper(I) bromide in N,N-dimethyl-formamide
参考文献
Takeuchi, Kumiko; Kohn, Todd J.; Sall, Daniel J.; Denney, Michael L.; McCowan, Jefferson R.; Smith, Gerry F.; Gifford-Moore, Donetta S.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 5 p. 759 - 764
反应条件
N-chloro-succinimide
参考文献
Kita, Yasuyuki; Egi, Masahiro; Takada, Takeshi; Tohma, Hirofumi
Synthesis, 1999 , # 5 p. 885 - 897
反应条件
1: 65 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 24 h / 20 °C 2: 55 percent / polyphosphoric acid / chlorobenzene / 24 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 38, # 5 p. 1025 - 1030
