4-(异喹啉-1-基)哌嗪-1-羧酸叔丁酯合成路线 （共 5 条）
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in phthalic acid dimethyl ester T=105 - 110°C;
参考文献
WO2006/71875 A1, ;
Page/Page column 82-83 ;
WO 2006/071875 A1
反应条件
hydrogen; palladium on activated charcoal in water; acetic acid T=50°C; 3 h;
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 23 p. 4910 - 4925
反应条件
1: Et3N / 1-methyl-pyrrolidin-2-one / 2 h / 70 °C 2: H2 / Pd/C / acetic acid; H2O / 3 h / 50 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 23 p. 4910 - 4925
反应条件
trifluoroacetic acid in dichloromethane 1.5 h; cooling;
参考文献
Matsuno, Kenji; Ushiki, Junko; Seishi, Takashi; Ichimura, Michio; Giese, Neill A.; Yu, Jin-Chen; Takahashi, Shusuke; Oda, Shoji; Nomoto, Yuji
Journal of Medicinal Chemistry, 2003 , vol. 46, # 23 p. 4910 - 4925
