1: 2,4,5-trimethoxyphenol With sodium hydride in N,N-dimethyl-formamide T=0 - 20°C; 0.5 h; Inert atmosphere; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 13 h;

potassium hydroxide in tetrahydrofuran; water Inert atmosphere;

暂无反应条件数据

oxygen; copper dichloride in water; ethyl acetate 3 h; Ambient temperature;

1: 94 percent / NaH / dimethylformamide / 1 h / Ambient temperature 2: 1.) HMPA, n-BuLi / 1.) THF, hexane, -40 deg C, 30 min, then -40 to -10 deg C, 1 h, -10 deg C, 1h, 2.) THF, hexane, overnight 3: 35 percent / ammonium cerium(IV) nitrate / acetonitrile; H2O / 1.) -7 deg C, 1 h, 2.) room temp., 2 h View Scheme

1: 94 percent / NaH / dimethylformamide / 1 h / Ambient temperature 2: 1.) HMPA, n-BuLi / 1.) THF, hexane, -40 deg C, 30 min, then -40 to -10 deg C, 1 h, -10 deg C, 1h, 2.) THF, hexane, overnight 3: 1.) ammonium cerium(IV) nitrate, 2.) HClO4 / 1.) CH3CN, H2O, -7 deg C, 1 h, then room temp., 2 h, 2.) CH2Cl2, room temp., 4 h View Scheme

1: 94 percent / NaH / dimethylformamide / 1 h / Ambient temperature 2: 1.) HMPA, n-BuLi / 1.) THF, hexane, -40 deg C, 30 min, then -40 to -10 deg C, 1 h, -10 deg C, 1h, 2.) THF, hexane, overnight 3: 1.) ammonium cerium(IV) nitrate, 2.) HClO4 / 1.) CH3CN, H2O, -7 deg C, 1 h, then room temp., 2 h, 2.) CH2Cl2, room temp., 4 h View Scheme

1: potassium carbonate / acetone / 18 h / 65 °C 2: hydrogen bromide / acetic acid / 6 h / 55 °C View Scheme

1: 94 percent / NaH / dimethylformamide / 1 h / Ambient temperature 2: 1.) HMPA, n-BuLi / 1.) THF, hexane, -40 deg C, 30 min, then -40 to -10 deg C, 1 h, -10 deg C, 1h, 2.) THF, hexane, overnight 3: 1.) ammonium cerium(IV) nitrate, 2.) HClO4 / 1.) CH3CN, H2O, -7 deg C, 1 h, then room temp., 2 h, 2.) CH2Cl2, room temp., 4 h View Scheme