4-甲基-1,3-恶唑-5-甲酸乙酯合成路线 （共 18 条）
反应条件
1: formamide With sulfuric acid T=120°C; P=48.7549 Torr; 2: FOXE 6.5 h;
参考文献
DSM IP ASSETS B.V.; FRANK, Eisele
Patent: WO2013/185976 A1, 2013 ;
Location in patent: Page/Page column 15-16 ;
反应条件
formamide in benzene
参考文献
Monsanto Company
Patent: US4303439 A1, 1981 ;
反应条件
formic acid 5 h; Heating;
参考文献
Sessions, E. Hampton; Jacobi, Peter A.
Organic Letters, 2006 , vol. 8, # 18 p. 4125 - 4128
反应条件
formic acid T=140 - 145°C; 6 h;
参考文献
Boulos, John; Schulman, Jerome
Journal of Heterocyclic Chemistry, 1998 , vol. 35, # 4 p. 859 - 863
反应条件
1: dimethylformamide / 1.5 h / 80 °C 2: 75 percent / formamide, sulfuric acid / toluene / 5 h View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 23, # 4 p. 330 - 332
Khimiko-Farmatsevticheskii Zhurnal, , vol. 23, # 4 p. 452 - 454
反应条件
(NH4)2CO3 T=100 - 110°C; 10 h;
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 32, p. 2348 - 2353,2315 - 2320
反应条件
1: SO2Cl2 2: 26 percent / HCOOH View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 43, # 2 p. 443 - 445
反应条件
ammonium hydroxide in water T=20°C; 10 h; Autoclave; ConcentrationReagent/catalystSolventTemperatureTime;
参考文献
DSM IP ASSETS B.V.; FISCHER, Jocelyn; KARRER, Philippe; VOLPE, Letizia; BONRATH, Werner
Patent: WO2013/160322 A1, 2013 ;
Location in patent: Page/Page column 6 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C;
参考文献
AVEXA LIMITED
Patent: WO2007/124546 A1, 2007 ;
Location in patent: Page/Page column 62 ;
