1-溴-3,5-二甲氧基苯合成路线 （共 64 条）
反应条件
1: 98 percent / t-BuLi; I2 / tetrahydrofuran; pentane / -78 - 20 °C
2: 93 percent / aq. HI / 24 h / Heating
View Scheme
参考文献
Cain, Matthew F.; Forrest, William P.; Peryshkov, Dmitry V.; Schrock, Richard R.; Mueller, Peter
Journal of the American Chemical Society, 2013 , vol. 135, # 41 p. 15338 - 15341
反应条件
tris-(dibenzylideneacetone)dipalladium(0); Me3SnNMe2; triphenylphosphine in toluene
Sonogashira coupling; 8 h; Inert atmosphereReflux;
参考文献
Cai, Liangzhen; Yang, Dujuan; Sun, Zhonghua; Tao, Xiaochun; Cai, Lisheng; Pike, Victor W.
Chinese Journal of Chemistry, 2011 , vol. 29, # 5 p. 1059 - 1062
反应条件
1: triethylamine; copper(l) iodide; triphenylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / 80 °C / |Inert atmosphere
2: palladium 10 on activated carbon; hydrogen / dichloromethane / 4 h / 20 °C / 2327.23 Torr / |Inert atmosphere
View Scheme
参考文献
Morales, Paula; Azofra, Luis Miguel; Cumella, Jose; Hernandez-Folgado, Laura; Roldan, Maria; Alkorta, Ibon; Jagerovic, Nadine
Arkivoc, 2014 , vol. 2014, # 2 p. 319 - 332
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in N,N-dimethyl-formamide
T=90°C; Sonogashira type cross-coupling; Inert atmosphere;
参考文献
Panda, Biswajit; Sarkar, Tarun K.
Tetrahedron Letters, 2010 , vol. 51, # 2 p. 301 - 305
