1-溴-3,5-二甲氧基苯合成路线 （共 64 条）
反应条件
1: copper-powder / 220 - 230 °C
2: HI; acetic acid
View Scheme
参考文献
Dean; Whalley
Journal of the Chemical Society, 1954 , p. 4638,4640
反应条件
potassium hydroxide; trichlorophosphate in N,N-dimethyl-formamide
T=20 - 90°C; Inert atmosphere;
参考文献
Persich, Peter; Llaveria, Josep; Lhermet, Rudy; Deharo, Teresa; Stade, Robert; Kondoh, Azusa; Fuerstner, Alois
Chemistry - A European Journal, 2013 , vol. 19, # 39 p. 13047 - 13058
反应条件
1: With trichlorophosphate
T=0 - 90°C; Inert atmosphere;
2: With potassium hydroxide in water
pH=14; 12 h;
参考文献
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; SNYDER, Scott Alan; SHERWOOD, Trevor C.; ROSS, Audrey G.; OH, Hyunju; GHOSH, Sankar
Patent: WO2011/103442 A2, 2011 ;
Location in patent: Page/Page column 7; 61-62 ;
反应条件
1: 1.) magnesium turnings, iodine, 2.) tellurium shot / 1.) THF, reflux, 0.5 h, 2.) reflux, 3 h
2: 1.) sodium borohydride / 1.) THF, ethanol, 2.) room temperature, 0.5 h
3: 96 percent / aq. potassium hydroxide / ethanol / 2 h / 50 °C
View Scheme
参考文献
Detty,M.R.; Murray,B.J.
Journal of the American Chemical Society, 1983 , vol. 105, p. 883
反应条件
1: With sodium thiomethoxide in 1-methyl-pyrrolidin-2-one
T=100°C; 3 h; Inert atmosphere;
2: With hydrogenchloride in 1-methyl-pyrrolidin-2-one; water
T=20°C;
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2239253 A1, 2010 ;
Location in patent: Page/Page column 44 ;
EP 2239253 A1
反应条件
magnesium in anhydrous xylene; diethyl ether
参考文献
Pfizer Inc.
Patent: US4476131 A1, 1984 ;
反应条件
1: 98 percent / t-BuLi; I2 / tetrahydrofuran; pentane / -78 - 20 °C
2: 93 percent / aq. HI / 24 h / Heating
3: 62 percent / K2CO3 / acetone / 36 h / Heating
View Scheme
参考文献
Alberico, Dino; Rudolph, Alena; Lautens, Mark
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 775 - 781
反应条件
1: 98 percent / t-BuLi; I2 / tetrahydrofuran; pentane / -78 - 20 °C
2: 93 percent / aq. HI / 24 h / Heating
3: 58 percent / K2CO3 / acetone / 36 h / Heating
View Scheme
参考文献
Alberico, Dino; Rudolph, Alena; Lautens, Mark
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 775 - 781
反应条件
1: 98 percent / t-BuLi; I2 / tetrahydrofuran; pentane / -78 - 20 °C
2: 93 percent / aq. HI / 24 h / Heating
3: 34 percent / K2CO3 / acetone / 24 h / Heating
View Scheme
参考文献
Alberico, Dino; Rudolph, Alena; Lautens, Mark
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 775 - 781
反应条件
1: 98 percent / t-BuLi; I2 / tetrahydrofuran; pentane / -78 - 20 °C
2: 93 percent / aq. HI / 24 h / Heating
3: 50 percent / K2CO3 / butan-2-one / 24 h / Heating
View Scheme
参考文献
Alberico, Dino; Rudolph, Alena; Lautens, Mark
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 775 - 781
