1-溴-3,5-二甲氧基苯合成路线 （共 64 条）
反应条件
1: With hydrogen bromide; sodium nitrite T=0°C; 2: With hydrogen bromide; copper(I) bromide 0.5 h; Heating;
参考文献
Lu, Dai; Meng, Zhaoxing; Thakur, Ganesh A.; Fan, Pusheng; Steed, John; Tartal, Cindy L.; Hurst, Dow P.; Reggio, Patricia H.; Deschamps, Jeffrey R.; Parrish, Damon A.; George, Clifford; Jaerbe, Torbjoern U. C.; Lamb, Richard J.; Makriyannis, Alexandras
Journal of Medicinal Chemistry, 2005 , vol. 48, # 14 p. 4576 - 4585
反应条件
copper(ll) bromide in methanol T=80°C;
参考文献
Murphy, Jaclyn M.; Liao, Xuebin; Hartwig, John F.
Journal of the American Chemical Society, 2007 , vol. 129, # 50 p. 15434 - 15435
反应条件
[bis(acetoxy)iodo]benzene; sodium bromide 0.5 h;
参考文献
Karade; Tiwari; Huple; Siddiqui
Journal of Chemical Research, 2006 , # 6 p. 366 - 368
反应条件
copper(l) iodide in N,N-dimethyl-formamide 23 h; Heating;
参考文献
Cammidge, Andrew N.; King, Amy S.H.
Tetrahedron Letters, 2006 , vol. 47, # 31 p. 5569 - 5572
反应条件
2,2'-azo-bisisobutyronitrile; trichloromonobromomethane; Fonderma 0.25 h; Heating;
参考文献
Dol, Georg C.; Kamer, Paul C. J.; Van Leeuwen, Piet W. N. M.
European Journal of Organic Chemistry, 1998 , # 2 p. 359 - 364
反应条件
Cu2Cl2; air in N,N-dimethyl-formamide T=110°C;
参考文献
Organic Preparations and Procedures International, , vol. 35, # 2 p. 225 - 227
反应条件
1: 99 percent / thionyl chloride / dimethylformamide / 18 h / Heating 2: 60 percent / AIBN, CBrCl3, 2-mercaptopyridine N-oxide sodium salt / 0.25 h / Heating View Scheme
参考文献
European Journal of Organic Chemistry, , # 2 p. 359 - 364
参考文献
Acta Chemica Scandinavica (1947-1973), , vol. 8, p. 728,732
反应条件
in acetic acid Ambient temperaturecompetitive bromination with p-dimethoxybenzene;
参考文献
Tetrahedron, , vol. 38, # 8 p. 1105 - 1112
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C 1.3: 20 °C / pH 2 2.1: potassium carbonate / triphenylphosphine; palladium diacetate / ethylene glycol dimethyl ether; water / 24 h / 20 °C / Inert atmosphere View Scheme
参考文献
REGENTS OF THE UNIVERSITY OF MINNESOTA; XING, Chengguo
Patent: WO2008/118802 A1, 2008 ;
