2,2-二甲基-3-丁烯酸苄酯合成路线 (共 2 条)
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide
参考文献
Murphy, Paul V.; Hubbard, Rod E.; Manallack, David T.; Wills, Ruth E.; Montana, John G.; Taylor, Richard J. K.
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 12 p. 2421 - 2439
反应条件
triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide T=20 - 80°C;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; RUAH, Sara, Hadida, S.; GROOTENHUIS, Peter, D., J.; VAN GOOR, Fredrick; MILLER, Mark, T.; MCCARTNEY, Jason; ZHOU, Jinglan; BEAR, Brian; NUMA, Mehdi, Michel, Djamel
Patent: WO2010/53471 A1, 2010 ;
Location in patent: Page/Page column 60-61 ;