1-壬基-2,5-吡咯二酮合成路线 （共 4 条）
反应条件
acetic anhydride in isobutyramide; water
参考文献
Ciba-Geigy Corporation
Patent: US4229351 A1, 1980 ;
反应条件
2,2-dimethyl-propanol; triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=-78 - 20°C; Mitsunobu coupling;
参考文献
Matuszak, Nicolas; Muccioli, Giulio G.; Labar, Geoffray; Lambert, Didier M.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 23 p. 7410 - 7420
反应条件
1: 79 percent / glacial acetic acid / Ambient temperature 2: 49 percent / Ac2O, NaOAC / 2 h / 90 °C View Scheme
参考文献
AstraZeneca AB
Patent: EP1075261 B1, 2006 ;
Location in patent: Page/Page column 9 ;
反应条件
sodium acetate; acetic anhydride T=90°C; 2 h;
参考文献
Kalgutkar, Amit S.; Crews, Brenda C.; Marnett, Lawrence J.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 8 p. 1692 - 1703
