4-溴-3,4-二氢-2H-苯并[b]氧杂卓-5-酮合成路线 (共 4 条)
反应条件
bromine in diethyl ether T=0 - 30°C; 2 h;
参考文献
Maiti, Swaraj B.; Ray Chaudhuri, S. R.; Chatterjee, Amareshwar
Synthesis, 1987 , # 9 p. 806 - 809
反应条件
1: PPA / 100 °C 2: hydrogen bromide; bromine / acetic acid View Scheme
参考文献
Packiarajan, Mathivanan; Marzabadi, Mohammad R.; Desai, Mahesh; Lu, Yalei; Noble, Stewart A.; Wong, Wai C.; Jubian, Vrej; Chandrasena, Gamini; Wolinsky, Toni D.; Zhong, Hualing; Walker, Mary W.; Wiborg, Ove.; Andersen, Kim
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5436 - 5441
反应条件
1: sodium methylate / methanol / Reflux 2: PPA / 100 °C 3: hydrogen bromide; bromine / acetic acid View Scheme
参考文献
Packiarajan, Mathivanan; Marzabadi, Mohammad R.; Desai, Mahesh; Lu, Yalei; Noble, Stewart A.; Wong, Wai C.; Jubian, Vrej; Chandrasena, Gamini; Wolinsky, Toni D.; Zhong, Hualing; Walker, Mary W.; Wiborg, Ove.; Andersen, Kim
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5436 - 5441
反应条件
in ethanol 72 h; Reflux;
参考文献
Genentech, Inc.
Patent: US2009/247567 A1, 2009 ;
Location in patent: Page/Page column 177-178 ;