N-[芴甲氧羰基]-D-谷氨酸烯丙基酯合成路线 （共 5 条）
反应条件
1: Fmoc-D-Glu(O-t-Bu)-OH With caesium carbonate in methanol; water pH=8; 2: allyl bromide in acetonitrile T=20°C; 21 h; 3: With trifluoroacetic acid in dichloromethane 0.833333 h;
参考文献
Fluxa, Viviana S.; Maillard, Noelie; Page, Malcolm G. P.; Reymond, Jean-Louis
Chemical Communications, 2011 , vol. 47, # 5 p. 1434 - 1436
反应条件
1: 96 percent / 1-hydroxybenzotriazole, benzotriazole-1-yl-oxy-tris-pyrrolidinophosphonium hexafluorophosphate, diisopropylethylamine / 15 h 2: 89 percent / trifluoroacetic acid / CH2Cl2 / 4 h View Scheme
参考文献
O'Brien, Dominic P.; Entress, Richard M. H.; Cooper, Matthew A.; O'Brien, Simon W.; Hopkinson, Andrew; Williams, Dudley H.
Journal of the American Chemical Society, 1999 , vol. 121, # 22 p. 5259 - 5265
反应条件
1: 1 h 2: sodium carbonate / 1,4-dioxane; water / 10 - 20 °C 3: 1,4-dioxane; water / 16 h / 20 °C View Scheme
参考文献
Agnihotri, Geetanjali; Ukani, Rehman; Malladi, Subbalakshmi S.; Warshakoon, Hemamali J.; Balakrishna, Rajalakshmi; Wang, Xinkun; David, Sunil A.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 5 p. 1490 - 1510
反应条件
1: 4-(N,N-dimethlyamino)pyridine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 4 h 2: 1 h 3: sodium carbonate / 1,4-dioxane; water / 10 - 20 °C 4: 1,4-dioxane; water / 16 h / 20 °C View Scheme
参考文献
Agnihotri, Geetanjali; Ukani, Rehman; Malladi, Subbalakshmi S.; Warshakoon, Hemamali J.; Balakrishna, Rajalakshmi; Wang, Xinkun; David, Sunil A.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 5 p. 1490 - 1510
反应条件
in 1,4-dioxane; water T=20°C; 16 h;
参考文献
Agnihotri, Geetanjali; Ukani, Rehman; Malladi, Subbalakshmi S.; Warshakoon, Hemamali J.; Balakrishna, Rajalakshmi; Wang, Xinkun; David, Sunil A.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 5 p. 1490 - 1510
