1,2-二(苯基)丙-1-酮合成路线 （共 138 条）
反应条件
1: 4-methyl-N'-(1-phenylethylidene)benzene-1-sulfonohydrazide With PCy3∙HBF4; bis(dibenzylideneacetone)-palladium(0); lithium tert-butylate
Inert atmosphere;
2: iodobenzene; carbon monoxide With triethylamine in acetonitrile
T=70°C;
参考文献
Zhang, Zhenhua; Liu, Yiyang; Gong, Mingxing; Zhao, Xiaokun; Zhang, Yan; Wang, Jianbo
Angewandte Chemie - International Edition, 2010 , vol. 49, # 6 p. 1139 - 1142
反应条件
1: With tri-tert-butyl phosphine; tetra-n-butylammonium difluorotriphenylsilicate(IV); bis(dibenzylideneacetone)-palladium(0) in toluene
T=95°C; Inert atmosphere;
2: With silica gel in toluene
参考文献
Guo, Yong; Tao, Guo-Hong; Blumenfeld, Alex; Shreeve, Jean'ne M.
Organometallics, 2010 , vol. 29, # 7 p. 1818 - 1823
反应条件
diisopropylamine in 1,2-dichloro-ethane
T=60°C; 43 h; Inert atmosphere;
参考文献
Peng, Cheng; Zhang, Wei; Yan, Guobing; Wang, Jianbo
Organic Letters, 2009 , vol. 11, # 7 p. 1667 - 1670
反应条件
PhMe2SiLi in tetrahydrofuran
1.) -78 deg C, 1.5 h, 2.) 0 deg C, 5 h;
参考文献
Fleming, Ian; Roberts, Richard S.; Smith, Stephen C.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 7 p. 1215 - 1228
反应条件
NaY zeolite; oxygen; methylene blue in dichloromethane
Photolysis;
参考文献
Sivaguru; Poon, Thomas; Franz, Roberto; Jockusch, Steffen; Adam, Waldemar; Turro, Nicholas J.
Journal of the American Chemical Society, 2004 , vol. 126, # 35 p. 10816 - 10817
反应条件
1: DIBAL
2: 92 percent / GaCl3; methylcyclohexane / 1 h / 20 °C
View Scheme
参考文献
Oshita, Masayuki; Okazaki, Takao; Ohe, Kouichi; Chatani, Naoto
Organic Letters, 2005 , vol. 7, # 2 p. 331 - 334
反应条件
1: 2-chloro-1,2-diphenyl-2-[(4-tolyl)sulfinyl]ethanol With 1,1-dimethylethylmagnesium chloride in tetrahydrofuran
T=-45°C; Inert atmosphere;
2: With isopropylmagnesium chloride in tetrahydrofuran
T=-45 - 20°C; Inert atmosphere;
3: methyl iodide With N,N,N',N',N'',N''-hexamethylphosphoric triamide in tetrahydrofuran
T=20°C; 1.5 h; Inert atmosphere;
参考文献
Fukuda, Shigehiko; Tsuji, Kazuhito; Musashi, Jun; Nonaka, Ryo; Kimura, Tsutomu; Satoh, Tsuyoshi
Synthesis, 2011 , # 22 art. no. F71511SS, p. 3615 - 3626
反应条件
water-d2; oxygen; copper diacetate in dichloromethane
T=80°C; 16 h; Concentration; Overall yield = 81 percent; regioselective reaction;
参考文献
Xu, Ze-Feng; Cai, Chen-Xin; Liu, Jin-Tao
Organic Letters, 2013 , vol. 15, # 9 p. 2096 - 2099
反应条件
water; oxygen; copper diacetate in dichloromethane
T=80°C; 3 h; regioselective reaction;
参考文献
Xu, Ze-Feng; Cai, Chen-Xin; Liu, Jin-Tao
Organic Letters, 2013 , vol. 15, # 9 p. 2096 - 2099
反应条件
oxygen; methylene blue in acetonitrile-D3
T=-15°C; 0.333333 h; Irradiation;
参考文献
Sivaguru; Solomon, Marissa R.; Saito, Hideaki; Poon, Thomas; Jockusch, Steffen; Adam, Waldemar; Inoue, Yoshihisa; Turro, Nicholas J.
Tetrahedron, 2006 , vol. 62, # 28 p. 6707 - 6717
