2,6-二氯-9-(四氢-2H-吡喃-2-基)-9h-嘌呤合成路线 （共 13 条）
反应条件
ammonia
T=20°C; 3 h;
参考文献
Borrmann, Thomas; Abdelrahman, Aliaa; Volpini, Rosaria; Lambertucci, Catia; Alksnis, Edgars; Gorzalka, Simone; Knospe, Melanie; Schiedel, Anke C.; Cristalli, Gloria; Mueller, Christa E.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 19 p. 5974 - 5989
反应条件
1.1: LDA / heptane; tetrahydrofuran; benzene / 1 h / -78 °C
1.2: 52 percent / hexachloroethane / heptane; tetrahydrofuran; benzene / 2 h / -78 °C
2.1: 40 percent / Fe(acac)3 / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 8 h / 20 °C
View Scheme
参考文献
Hocek, Michal; Pohl, Radek
Synthesis, 2004 , # 17 p. 2869 - 2876
反应条件
1.1: LDA / heptane; tetrahydrofuran; benzene / 1 h / -78 °C
1.2: 52 percent / hexachloroethane / heptane; tetrahydrofuran; benzene / 2 h / -78 °C
2.1: 23 percent / Fe(acac)3 / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 8 h / 20 °C
3.1: 85 percent / Dowex 50 X 8 (H(+)); H20 / ethanol / 1 h / Heating
View Scheme
参考文献
Hocek, Michal; Pohl, Radek
Synthesis, 2004 , # 17 p. 2869 - 2876
