(Z)-Alpha-氟肉桂酸合成路线 （共 15 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane
1.) -78 deg C, 1 h; 2.) 15 h room temperature;
参考文献
Coutrot, Ph.; Grison, C.; Sauvetre, R.
Journal of Organometallic Chemistry, 1987 , vol. 332, p. 1 - 8
反应条件
zinc; benzene
anschliessend Behandeln mit wss. H2SO4;
参考文献
McBee et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 1581
反应条件
1: 1,1,1,2-tetrafluoro-2-chloroethane With n-butyllithium in diethyl ether; hexane
T=-80°C; 0.5 h; Inert atmosphere;
2: benzaldehyde in diethyl ether; hexane
T=-80 - 0°C; 5 h; Inert atmosphere; stereospecific reactionFurther stages;
参考文献
Notsu, Keiji; Zushi, Yasuyuki; Ota, Shin; Kawasaki-Takasuka, Tomoko; Yamazaki, Takashi
Chemistry - A European Journal, 2011 , vol. 17, # 33 p. 9200 - 9208
反应条件
1: With n-butyllithium in tetrahydrofuran
T=-78°C; Wittig-Horner Reaction;
2: With bromine in tetrachloromethane
3: With sodium hydroxide in ethanol; water
参考文献
Eddarir, Said; Kajjout, Mohammed; Rolando, Christian
Tetrahedron, 2013 , vol. 69, # 6 p. 1735 - 1738
反应条件
bromine in tetrachloromethane
25 - 60 deg C, 10-120 min;
参考文献
Eddarir, Said; Francesch, Charlette; Mestdagh, Helene; Rolando, Christian
Tetrahedron Letters, 1990 , vol. 31, # 31 p. 4449 - 4452
反应条件
iso-propylmagnesium bromide in tetrahydrofuran
Horner-Wadsworth-Emmons reaction; 1 h; Heating;
参考文献
Sano, Shigeki; Teranishi, Rie; Nagao, Yoshimitsu
Tetrahedron Letters, 2002 , vol. 43, # 50 p. 9183 - 9186
反应条件
1: 56 percent / NBS, 70percent HF/Py / diethyl ether / 0.5 h / 0 °C
2: conc. NH4OH / 1 h / Ambient temperature
View Scheme
参考文献
Takeuchi, Yoshio; Takagi, Kumiko; Yamaba, Tomokazu; Nabetani, Manabu; Koizumi, Toru
Journal of Fluorine Chemistry, 1994 , vol. 68, # 2 p. 149 - 154
反应条件
sodium hydride in N,N-dimethyl-formamide
2 h;
参考文献
Elkik, Elias; Imbeaux-Oudotte, Michele
Bulletin de la Societe Chimique de France, 1987 , # 5 p. 861 - 866
反应条件
2: 10 percent / NaH (50percent in oil), / dimethylformamide / 2 h
View Scheme
参考文献
Elkik, Elias; Imbeaux-Oudotte, Michele
Bulletin de la Societe Chimique de France, 1987 , # 5 p. 861 - 866
反应条件
1: H2SO4
2: H2O
View Scheme
参考文献
Normant,J.F. et al.
Synthesis, 1975 , p. 122 - 125
