2-(2-氨基乙基)苯酚合成路线 （共 24 条）
反应条件
lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal 1.) THF, room temperature, 3 h, 2.) EtOH, 3.8 atm, 24 h; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 61, # 1 p. 223 - 227
反应条件
1: 100 percent / bromine / CH2Cl2 / 5.5 h / cooling in a CO2(s)/aceton bath 2: 65 percent / m-chloroperoxybenzoic acid / CHCl3 / 5 h / Heating 3: 103 percent / 1,5-diazabicyclo<5.4.0>undec-5-ene (DBU) / tetrahydrofuran / 24 h / 1) ice bath 2) room temperature 4: 61 percent / anhydrous hydrazine / CH2Cl2 / 24 h / Ambient temperature 5: NaOD / D2O; tetradeuteriomethanol View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 16 p. 3149 - 3155
反应条件
1: 61 percent / anhydrous hydrazine / CH2Cl2 / 24 h / Ambient temperature 2: NaOD / D2O; tetradeuteriomethanol View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 16 p. 3149 - 3155
反应条件
1: 65 percent / m-chloroperoxybenzoic acid / CHCl3 / 5 h / Heating 2: 103 percent / 1,5-diazabicyclo<5.4.0>undec-5-ene (DBU) / tetrahydrofuran / 24 h / 1) ice bath 2) room temperature 3: 61 percent / anhydrous hydrazine / CH2Cl2 / 24 h / Ambient temperature 4: NaOD / D2O; tetradeuteriomethanol View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 16 p. 3149 - 3155
反应条件
1: 103 percent / 1,5-diazabicyclo<5.4.0>undec-5-ene (DBU) / tetrahydrofuran / 24 h / 1) ice bath 2) room temperature 2: 61 percent / anhydrous hydrazine / CH2Cl2 / 24 h / Ambient temperature 3: NaOD / D2O; tetradeuteriomethanol View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 16 p. 3149 - 3155
反应条件
1: 100 percent / toluene / 1) 1h ambient temperature 2) 1h reflux 2: 53 percent / m-chloroperoxybenzoic acid / CH2Cl2 / Heating 3: 76 percent / bromine / CH2Cl2 / 2.5 h / -78 °C 4: 94 percent / 1,5-diazabicyclo<5.4.0>undec-5-ene (DBU) / tetrahydrofuran / 24 h / 1) ice bath 2) room temperature 5: 51 percent / anhydrous hydrazine / CH2Cl2 / 24 h / Ambient temperature 6: 92 percent / NaN3 / various solvent(s) / 0.75 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 16 p. 3149 - 3155
反应条件
1: 76 percent / bromine / CH2Cl2 / 2.5 h / -78 °C 2: 94 percent / 1,5-diazabicyclo<5.4.0>undec-5-ene (DBU) / tetrahydrofuran / 24 h / 1) ice bath 2) room temperature 3: 51 percent / anhydrous hydrazine / CH2Cl2 / 24 h / Ambient temperature 4: 92 percent / NaN3 / various solvent(s) / 0.75 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 16 p. 3149 - 3155
反应条件
1: 53 percent / m-chloroperoxybenzoic acid / CH2Cl2 / Heating 2: 76 percent / bromine / CH2Cl2 / 2.5 h / -78 °C 3: 94 percent / 1,5-diazabicyclo<5.4.0>undec-5-ene (DBU) / tetrahydrofuran / 24 h / 1) ice bath 2) room temperature 4: 51 percent / anhydrous hydrazine / CH2Cl2 / 24 h / Ambient temperature 5: 92 percent / NaN3 / various solvent(s) / 0.75 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 16 p. 3149 - 3155
反应条件
1: 51 percent / anhydrous hydrazine / CH2Cl2 / 24 h / Ambient temperature 2: 92 percent / NaN3 / various solvent(s) / 0.75 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 16 p. 3149 - 3155
反应条件
1: 94 percent / 1,5-diazabicyclo<5.4.0>undec-5-ene (DBU) / tetrahydrofuran / 24 h / 1) ice bath 2) room temperature 2: 51 percent / anhydrous hydrazine / CH2Cl2 / 24 h / Ambient temperature 3: 92 percent / NaN3 / various solvent(s) / 0.75 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 16 p. 3149 - 3155
