4,5-二氟-2-硝基苯甲酸合成路线 （共 16 条）
反应条件
sulfuric acid; nitric acid T=20°C; 3 h;
参考文献
Jung, Jae-Chul; Baek, Shin; Park, Oee-Sook
Farmaco, 2001 , vol. 56, # 9 p. 664 - 676
反应条件
CrO3; sulfuric acid in water; acetic acid; ethyl acetate
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide 2.1: sulfuric acid / |Reflux 2.2: 20 °C / 760.05 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 14 p. 4132 - 4140
反应条件
copper in 1-methyl-pyrrolidin-2-one T=250°C; 0.5 h;
参考文献
Zhang, Yun; Jamison, Timothy F.; Patel, Sejal; Mainolfi, Nello
Organic Letters, 2011 , vol. 13, # 2 p. 280 - 283
反应条件
lithium aluminium tetrahydride; sulfur trioxide pyridine complex in diethyl ether
参考文献
Amberg, Wilhelm; Netz, Astrid; Kling, Andreas; Ochse, Michael; Lange, Udo; Hutchins, Charles W.; Garcia-Ladona, Francisco Javier; Wernet, Wolfgang; Hahn, Alfred
Patent: US2010/41698 A1, 2010 ;
Location in patent: Page/Page column 48 ;
反应条件
1: potassium hydroxide; water / 0.83 h / 50 - 90 °C 2: methanol; sulfuric acid / 10 - 75 °C / |Inert atmosphere View Scheme
参考文献
Boehringer Ingelheim International GmbH; Busacca, Carl A.; Eriksson, Magnus C.; Xu, Jinghua; Zeng, Xingzhong
Patent: US8519176 B1, 2013 ;
反应条件
hydrogen; palladium hydroxide on carbon in methanol T=20°C; 2 h;
参考文献
WO2003/106435 A1, ;
Page 290; 291; 332 ;
WO 03/106435 A1
反应条件
thionyl chloride; urea in toluene T=100°C; 3 h;
参考文献
Chen, Ling; Li, Honglin; Liu, Jun; Zhang, Luyong; Liu, Hong; Jiang, Hualiang
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 21 p. 6763 - 6774
参考文献
ULYSSES PHARMACEUTICAL PRODUCTS INC.
Patent: WO2008/113161 A1, 2008 ;
Location in patent: Page/Page column 26 ;
反应条件
sulfuric acid 48 h; Heating / reflux;
参考文献
PORTOLA PHARMACEUTICALS, INC.
Patent: WO2008/36843 A2, 2008 ;
Location in patent: Page/Page column 33 ;
WO 2008/036843 A2
