3-甲氧基-2-硝基吡啶合成路线 （共 20 条）
反应条件
potassium carbonate T=20°C; 1 h; Reflux;
参考文献
WO2014/28669 A1, ;
Paragraph 00586 ;
反应条件
potassium hydroxide in dimethyl sulfoxide 0.333333 h;
参考文献
Williamson, David A.; Bowler, Bruce E.
Tetrahedron, 1996 , vol. 52, # 38 p. 12357 - 12372
反应条件
potassium carbonate in acetone 2 h; Heating;
参考文献
Barlin, Gordon B.; Davies, Les P.; Harrison, Peter W.
Australian Journal of Chemistry, 1995 , vol. 48, # 5 p. 1031 - 1038
反应条件
sulfuric acid; nitric acid
参考文献
Journal of the American Chemical Society, , vol. 69, p. 1147,1148
Chemische Berichte, , vol. 61, p. 1028
反应条件
1: 150 - 160 °C 2: concentrated sulfuric acid; fuming nitric acid View Scheme
参考文献
Chemische Berichte, , vol. 61, p. 1028
参考文献
Tetrahedron Letters, , vol. 51, # 38 p. 5035 - 5037
反应条件
1: sulfuric acid; nitric acid / 20 - 30 °C 2: sodium carbonate; toluene View Scheme
参考文献
Pharmaceutical Bulletin, , vol. 5, p. 350,352
参考文献
Synthesis, , # 3 p. 383 - 387
反应条件
1.1: ethanol; water; calcium chloride; iron / 12.5 h / 75 °C 2.1: bromine / acetic acid / 16.5 h / 20 °C 2.2: 0 °C / pH 7 View Scheme
参考文献
BIOGEN IDEC MA INC.; HUTCHINGS, Richard, H.; JONES, John, Howard; CHAO, Jianhua; ENYEDY, Istvan, J.; MARCOTTE, Douglas
Patent: WO2014/28669 A1, 2014 ;
Location in patent: Paragraph 00587 ;
反应条件
hydrazine hydrate Heating;
参考文献
Williamson, David A.; Bowler, Bruce E.
Tetrahedron, 1996 , vol. 52, # 38 p. 12357 - 12372
