2-甲氧基-3-硝基吡啶合成路线 （共 14 条）
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran; methanol T=20°C; Hydrogenation; 1 h;
参考文献
Dolle, Valerie; Nguyen, Chi Hung; Bisagni, Emile
Tetrahedron, 1997 , vol. 53, # 37 p. 12505 - 12524
反应条件
hydrogen; sulfided platinum in ethanol T=150°C; P=51714.8 Torr; 8 h;
参考文献
Balko; Brinkmeyer
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 4 p. 901 - 905
反应条件
1.1: hydrogen / palladium 10 on activated carbon / methanol / 4 h
2.1: N-bromosuccinmide / N,N-dimethyl-formamide / -30 °C
3.1: hydrogenchloride; sodium nitrite / water / 0.33 h / 5 °C
3.2: 5 - 60 °C
4.1: n-butyllithium / diethyl ether / 1 h / -80 °C / Inert atmosphere
4.2: 1 h / -80 °C / Inert atmosphere
4.3: -80 °C
View Scheme
参考文献
TAISHO PHARMACEUTICAL CO., LTD; NISSAN CHEMICAL INDUSTRIES, LTD.
Patent: US2011/237791 A1, 2011 ;
反应条件
1: hydrogen; palladium 10 on activated carbon / methanol / 3 h
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 - 27 °C
View Scheme
参考文献
HEPTARES THERAPEUTICS LIMITED; CONGREVE, Miles Stuart; CHRISTOPHER, John Andrew; TEHAN, Benjamin Gerald; KLAIR, Sukhbinder Singh; AVES, Sarah Joanne
Patent: WO2014/6402 A1, 2014 ;
