3-(4-羟基-苯基)-丙醛合成路线 （共 16 条）
反应条件
tetrabutyl-ammonium chloride; sodium acetate; palladium diacetate in acetonitrile T=0°C; Mizoroki-Heck reaction; 6 h; Inert atmosphere; regioselective reaction;
参考文献
ZYLUM BETEILIGUNGSGESELLSCHAFT MBH and CO. PATENTE II KG; Boege, Nicolas; Kreipl, Andreas; Schmidt, Bernd; Hoelter, Frank; Berger, René
Patent: US2013/53598 A1, 2013 ;
Location in patent: Paragraph 0049; 0050; 0051; 0052; 0053 ;
反应条件
sodium acetate; palladium diacetate in methanol T=0°C; Heck Reaction; 6 h;
参考文献
ZYLUM BETEILIGUNGSGESELLSCHAFT MBH and CO. PATENTE II KG; Boege, Nicolas; Kreipl, Andreas; Schmidt, Bernd; Hoelter, Frank; Berger, René
Patent: US2013/53598 A1, 2013 ;
Location in patent: Paragraph 0049; 0050; 0051; 0052; 0053 ;
反应条件
hydrogen; palladium on activated charcoal in methanol P=760 Torr; Ambient temperature;
参考文献
Herbert, Richard B.; Kattah, Abdullah E.
Tetrahedron, 1990 , vol. 46, # 20 p. 7105 - 7118
反应条件
lithium aluminium tetrahydride in diethyl ether T=0°C; 3 h;
参考文献
Chen, Yu-Chen; Muhlrad, Andras; Shteyer, Arie; Vidson, Marina; Bab, Itai; Chorev, Michael
Journal of Medicinal Chemistry, 2002 , vol. 45, # 8 p. 1624 - 1632
反应条件
[BMIm][HSO4] T=20°C; Friedel-Crafts Alkylation; 24 h; regioselective reaction;
参考文献
Guo, Hui; Zhuang, Yu Wei; Cao, Jian; Zhang, Guo Bao
Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 9 p. 2594 - 2596
反应条件
hydrogen; (CO)4(PEtPh2)W(μ-PPh2)Rh(CO)(PPh3) in toluene T=25°C; P=760 Torr; 50 h; Title compound not separated from byproducts;
参考文献
Yamane, Motoki; Yukimura, Noriaki; Ishiai, Hiroshi; Narasaka, Koichi
Chemistry Letters, 2006 , vol. 35, # 5 p. 540 - 541
反应条件
sodium hydrogencarbonate; 3-pyrrolidin-2-yl-pyridine in phosphate buffer; dimethyl sulfoxide T=32°C; pH=7.0; 7 h;
参考文献
Brogan, Andrew P.; Dickerson, Tobin J.; Janda, Kim D.
Chemical Communications, 2007 , # 46 p. 4952 - 4954
反应条件
sodium acetate; palladium diacetate in methanol T=0°C; Mizoroki-Heck reaction; 6 h; Inert atmosphere; stereoselective reaction;
参考文献
Schmidt, Bernd; Hoelter, Frank; Kelling, Alexandra; Schilde, Uwe
Journal of Organic Chemistry, 2011 , vol. 76, # 9 p. 3357 - 3365
反应条件
1: 62 percent / Et3N; DMAP; DCC / CH2Cl2 / 20 °C 2: 77 percent / LiAlH4 / diethyl ether / 3 h / 0 °C View Scheme
参考文献
Herbert, Richard B.; Kattah, Abdullah E.
Tetrahedron, 1990 , vol. 46, # 20 p. 7105 - 7118
反应条件
1: 45.3 percent / Ag2CO3-celite / benzene / Heating 2: 100 percent / H2 / 10percent Pd-C / methanol / 760 Torr / Ambient temperature View Scheme
参考文献
Herbert, Richard B.; Kattah, Abdullah E.
Tetrahedron, 1990 , vol. 46, # 20 p. 7105 - 7118
