5-氰基-1H-吲哚-3-乙酸合成路线 （共 3 条）
反应条件
1: With lithium hydroxide; water in tetrahydrofuran T=20°C; 3 h; 2: With hydrogenchloride; water in tetrahydrofuran; ethyl acetate
参考文献
Bristol-Myers Squibb Company
Patent: US2007/49589 A1, 2007 ;
Location in patent: Page/Page column 14 ;
US 20070049589 A1
反应条件
1: diethyl ether / 3.5 h / 20 °C 2: 18 h / 20 °C 3: 22.6 percent / Et3SiH; TFA / 20 h / 20 °C 4: KOH / methanol / 18 h / 20 °C View Scheme
参考文献
Han; Dominguez; Stouten; Park; Duffy; Galemmo Jr.; Rossi; Alexander; Smallwood; Wong; Wright; Luettgen; Knabb; Wexler
Journal of Medicinal Chemistry, 2000 , vol. 43, # 23 p. 4398 - 4415
反应条件
1: 22.6 percent / Et3SiH; TFA / 20 h / 20 °C 2: KOH / methanol / 18 h / 20 °C View Scheme
参考文献
Han; Dominguez; Stouten; Park; Duffy; Galemmo Jr.; Rossi; Alexander; Smallwood; Wong; Wright; Luettgen; Knabb; Wexler
Journal of Medicinal Chemistry, 2000 , vol. 43, # 23 p. 4398 - 4415
