2-氯-6,7-二甲氧基-3H-喹唑啉-4-酮合成路线 （共 8 条）
反应条件
potassium hydroxide in tetrahydrofuran; water T=22°C; Inert atmosphereLarge scale;
参考文献
Connolly, Terrence J.; Matchett, Michael; Sarma, Keshab
Organic Process Research and Development, 2005 , vol. 9, # 1 p. 80 - 87
反应条件
1: 85 percent / POCl3, PhNMe2 2: NaOH / tetrahydrofuran; H2O View Scheme
参考文献
DeRuiter; Brubaker; Millen; Riley
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 627 - 629
反应条件
1: 70percent HNO3, HOAc 2: SnCl2, HCl 3: NaOH / H2O; methanol 4: HOAc / H2O 5: 85 percent / POCl3, PhNMe2 6: NaOH / tetrahydrofuran; H2O View Scheme
参考文献
DeRuiter; Brubaker; Millen; Riley
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 627 - 629
反应条件
1: SnCl2, HCl 2: NaOH / H2O; methanol 3: HOAc / H2O 4: 85 percent / POCl3, PhNMe2 5: NaOH / tetrahydrofuran; H2O View Scheme
参考文献
DeRuiter; Brubaker; Millen; Riley
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 627 - 629
反应条件
1: NaOH / H2O; methanol 2: HOAc / H2O 3: 85 percent / POCl3, PhNMe2 4: NaOH / tetrahydrofuran; H2O View Scheme
参考文献
DeRuiter; Brubaker; Millen; Riley
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 627 - 629
反应条件
1: HOAc / H2O 2: 85 percent / POCl3, PhNMe2 3: NaOH / tetrahydrofuran; H2O View Scheme
参考文献
DeRuiter; Brubaker; Millen; Riley
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 627 - 629
反应条件
in 2-methoxy-ethanol
参考文献
Becker, Cyrus Kephra; Caroon, Joan Marie; Melville, Chris Richard; Padilla, Fernando; Pfister, Jurg Roland; Zhang, Xiaoming
Patent: US2003/69230 A1, 2003 ;
US 20030069230 A1
反应条件
sodium azide in ethanol
18 h; Heating;
参考文献
Bencteux, Edith; Houssin, Raymond; Henichart, Jean-Pierre
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 4 p. 1375 - 1378
