2-氨基-4,5-二乙氧基苯甲酸合成路线 （共 9 条）
反应条件
hydrogen; palladium on activated carbon in methanol
参考文献
Rexahan Corporation
Patent: US2005/187231 A1, 2005 ;
Location in patent: Page/Page column 18-19 ;
反应条件
sodium hydroxide 1 h; Heating;
参考文献
VanBrocklin, Henry F.; Lim, John K.; Coffing, Stephanie L.; Hom, Darren L.; Negash, Kitaw; Ono, Michele Y.; Gilmore, Jennifer L.; Bryant, Ianthe; Riese II, David J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7445 - 7456
反应条件
1: 67 percent / HNO3; acetic acid / 2.08 h / 20 °C 2: 44 percent / SnCl2; aq. HCl / 2 h / 20 °C View Scheme
参考文献
VanBrocklin, Henry F.; Lim, John K.; Coffing, Stephanie L.; Hom, Darren L.; Negash, Kitaw; Ono, Michele Y.; Gilmore, Jennifer L.; Bryant, Ianthe; Riese II, David J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7445 - 7456
反应条件
1: POCl3 2: water; HNO3 3: KMnO4 4: palladium/charcoal; ethanol / Hydrogenation View Scheme
参考文献
Szabo; Vinkler
Acta Chimica Academiae Scientiarum Hungaricae, 1958 , vol. 17, p. 201,207
反应条件
1: water; HNO3 2: KMnO4 3: palladium/charcoal; ethanol / Hydrogenation View Scheme
参考文献
Szabo; Vinkler
Acta Chimica Academiae Scientiarum Hungaricae, 1958 , vol. 17, p. 201,207
反应条件
1: KMnO4 2: palladium/charcoal; ethanol / Hydrogenation View Scheme
参考文献
Szabo; Vinkler
Acta Chimica Academiae Scientiarum Hungaricae, 1958 , vol. 17, p. 201,207
反应条件
1: T=210°C; 0.25 h; Heating / reflux; 2: With sodium hydroxide in water T=80°C;
参考文献
Rexahan Corporation
Patent: US2005/187231 A1, 2005 ;
Location in patent: Page/Page column 19 ;
反应条件
1: 57 percent / 80 - 200 °C 2: 73 percent / oxalyl chloride; DMF / 1,2-dichloro-ethane / 2.5 h / Heating View Scheme
参考文献
VanBrocklin, Henry F.; Lim, John K.; Coffing, Stephanie L.; Hom, Darren L.; Negash, Kitaw; Ono, Michele Y.; Gilmore, Jennifer L.; Bryant, Ianthe; Riese II, David J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7445 - 7456
反应条件
trichlorophosphate
2 h; Heating;
参考文献
Rosini, Michela; Mancini, Francesca; Tarozzi, Andrea; Colizzi, Francesco; Andrisano, Vincenza; Bolognesi, Maria L.; Hrelia, Patrizia; Melchiorre, Carlo
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 7846 - 7853
