2-氨基-4,5-二乙氧基苯甲酸甲酯合成路线 （共 6 条）
反应条件
sodium hydroxide 1 h; Heating;
参考文献
VanBrocklin, Henry F.; Lim, John K.; Coffing, Stephanie L.; Hom, Darren L.; Negash, Kitaw; Ono, Michele Y.; Gilmore, Jennifer L.; Bryant, Ianthe; Riese II, David J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7445 - 7456
反应条件
1: 76 percent / aq. NaOH / 1 h / Heating 2: 57 percent / 80 - 200 °C View Scheme
参考文献
VanBrocklin, Henry F.; Lim, John K.; Coffing, Stephanie L.; Hom, Darren L.; Negash, Kitaw; Ono, Michele Y.; Gilmore, Jennifer L.; Bryant, Ianthe; Riese II, David J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7445 - 7456
反应条件
1: 76 percent / aq. NaOH / 1 h / Heating 2: 57 percent / 80 - 200 °C 3: 73 percent / oxalyl chloride; DMF / 1,2-dichloro-ethane / 2.5 h / Heating View Scheme
参考文献
VanBrocklin, Henry F.; Lim, John K.; Coffing, Stephanie L.; Hom, Darren L.; Negash, Kitaw; Ono, Michele Y.; Gilmore, Jennifer L.; Bryant, Ianthe; Riese II, David J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7445 - 7456
反应条件
N,N-dimethyl-cyclohexylamine; phosphorus pentoxide
T=170 - 210°C; 4 h;
参考文献
Rosini, Michela; Mancini, Francesca; Tarozzi, Andrea; Colizzi, Francesco; Andrisano, Vincenza; Bolognesi, Maria L.; Hrelia, Patrizia; Melchiorre, Carlo
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 7846 - 7853
反应条件
1: 12 percent / N,N-dimethylcyclohexylamine; P2O5 / 4 h / 170 - 210 °C
2: 0.34 g / POCl3 / 2 h / Heating
View Scheme
参考文献
Rosini, Michela; Mancini, Francesca; Tarozzi, Andrea; Colizzi, Francesco; Andrisano, Vincenza; Bolognesi, Maria L.; Hrelia, Patrizia; Melchiorre, Carlo
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 7846 - 7853
反应条件
1: 21 percent / N,N-dimethylcyclohexylamine; P2O5 / 4 h / 170 - 210 °C
2: 33 percent / POCl3 / 2 h / Heating
View Scheme
参考文献
Rosini, Michela; Mancini, Francesca; Tarozzi, Andrea; Colizzi, Francesco; Andrisano, Vincenza; Bolognesi, Maria L.; Hrelia, Patrizia; Melchiorre, Carlo
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 7846 - 7853
