N-苄氧羰基-L-亮氨酸合成路线 （共 125 条）
反应条件
T=40°C; gepufferte wss. Loesung (pH 5);
参考文献
Bergmann; Fraenkel-Conrat
Journal of Biological Chemistry, 1937 , vol. 119, p. 707,717
反应条件
1: PCl3; pyridine 2: methanol; aqueous NaOH 3: palladium; acetic acid; aqueous methanol / Hydrogenation View Scheme
参考文献
Grassmann; Wuensch
Chemische Berichte, 1958 , vol. 91, p. 449,453
反应条件
1: PCl3 2: dioxane; aqueous NaOH 3: palladium; acetic acid; aqueous methanol / Hydrogenation View Scheme
参考文献
Farrington et al.
Journal of the Chemical Society, 1957 , p. 1407,1410
反应条件
1: DCC; HOBt 2: hydrogen / Pd View Scheme
参考文献
Akazome, Motohiro; Hirabayashi, Atsushi; Takaoka, Kousuke; Nomura, Satoru; Ogura, Katsuyuki
Tetrahedron, 2005 , vol. 61, # 5 p. 1107 - 1113
反应条件
Pseudomonas aeruginosa PT121 protease in water; dimethyl sulfoxide Enzymatic reaction;
参考文献
Sun, Honglin; He, Bingfang; Xu, Jiaxing; Wu, Bin; Ouyang, Pingkai
Green Chemistry, 2011 , vol. 13, # 7 p. 1680 - 1685
反应条件
1: N-[(benzyloxy)carbonyl]-L-leucine With chloroformic acid ethyl ester; triethylamine in tetrahydrofuran; diethyl ether T=-25°C; 0.5 h; 2: diazomethane in tetrahydrofuran; diethyl ether T=-10 - 20°C; 3 h;
参考文献
Bures, Filip; Kulhanek, Jiri
Tetrahedron Asymmetry, 2005 , vol. 16, # 7 p. 1347 - 1354
反应条件
1: Et3N / diethyl ether; tetrahydrofuran / 0.5 h / -25 °C 2: diethyl ether / 3 h / -10 °C View Scheme
参考文献
Kaltenbronn; Hudspeth; Lunney; Michniewicz; Nicolaides; Repine; Roark; Stier; Tinney; Woo; Essenburg
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 838 - 845
反应条件
thionyl chloride in tetrahydrofuran T=40°C; 4 h; Inert atmosphere;
参考文献
Xu, Xianghui; Yuan, Hui; Chang, Jing; He, Bin; Gu, Zhongwei
Angewandte Chemie - International Edition, 2012 , vol. 51, # 13 p. 3130 - 3133
反应条件
in benzene T=60 - 70°C; 0.25 h;
参考文献
Takagi, Ryukichi; Begum, Shahnaz; Siraki, Akiko; Yoneshige, Arata; Koyama, Kin-ichirou; Ohkata, Katsuo
Heterocycles, 2004 , vol. 64, p. 129 - 141
反应条件
1: dicyclohexylcarbodiimide 2: catalytic hydrogenation View Scheme
参考文献
Ohyama, Satoshi; Ishibashi, Norio; Tamura, Masahiro; Nishizaki, Hiroshi; Okai, Hideo
Agricultural and Biological Chemistry, 1988 , vol. 52, # 3 p. 871 - 872
