N-苄氧羰基-L-亮氨酸合成路线 （共 125 条）
参考文献
Wieland; Heinke
Justus Liebigs Annalen der Chemie, 1958 , vol. 615, p. 184,195
反应条件
1: 75 percent / ethyl 1,2-dihydro-2-ethoxyquinoline-1-carboxylate / CH2Cl2 / 24 h / Ambient temperature
2: 35 percent Spectr. / ammonium hydrogen carbonate, H2O / CH2Cl2 / 24 h / α-chymotrypsin
View Scheme
参考文献
Ricca, Jean-Marc; Crout, David H. G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 11 p. 1225 - 1234
反应条件
1: 63 percent / thermolysin / ethyl acetate; various solvent(s) / 20 h / 37 °C
2: HBr, glacial AcOH
4: HCl, AcOH
View Scheme
参考文献
Kuhl, Peter; Doering, Guenter; Neubert, Klaus; Jakubke, Hans-Dieter
Monatshefte fuer Chemie, 1984 , vol. 115, p. 423 - 430
反应条件
4-methyl-morpholine; thylchlorophormate in ethyl acetate
-15 deg C, 1 h, then RT, 12 h;
参考文献
Falorni; Giacomelli; Satta; Cossu
Synthesis, 1994 , # 4 p. 391 - 395
反应条件
1: 4-methylmorpholine / ethyl acetate / 0.25 h / -15 °C
2: 4-methylmorpholine / ethyl acetate / 13 h / -15 - 20 °C
View Scheme
参考文献
Falorni, Massimo; Satta, Michele; Conti, Sandra; Giacomelli, Giampaolo
Tetrahedron: Asymmetry, 1993 , vol. 4, # 11 p. 2389 - 2398
