N-苄氧羰基-L-亮氨酸合成路线 （共 125 条）
反应条件
1: DCC
2: DDQ / toluene / Heating
3: 1.) Hg(OTFA)2, 2.) KI, 3.) I2
4: Pd2(dba)3, P(o-tolyl)3, K2CO3 / toluene / Heating
5: Zn, AcOH
6: DCC
7: 93 percent / Zn, AcOH / ethyl acetate
8: 82 percent / Et3N, DMAP
9: 91 percent / Bu3P / benzene / 60 °C
10: 3-n-butyl-1,2-benzisothiazole-1,1-dioxide oxide / 48 h
11: NaBH4, AcOH
12: 87 percent / H2 / Pd/C / methanol / 0.25 h / 760 Torr
View Scheme
参考文献
He; Foxman; Snider
Journal of the American Chemical Society, 1998 , vol. 120, # 25 p. 6417 - 6418
反应条件
1: (i) ClCO2Et, Et3N, CHCl3, (ii) /BRN= 1722028/
2: aq. NaOH / acetone
View Scheme
参考文献
Okumura,Y.; Sakurai,A.
Bulletin of the Chemical Society of Japan, 1973 , vol. 46, p. 2190 - 2193
反应条件
1: diethyl ether; PCl5 / 0 °C
2: ethyl acetate; diethyl ether / 0 °C
3: aqueous methanol.NaOH / Hydrogenolyse des Reaktionsprodukts an Palladium in Essigsaeure enthaltendem wss.Methanol
View Scheme
参考文献
Bergmann; Zervas; Fruton
Journal of Biological Chemistry, 1936 , vol. 115, p. 593,607
反应条件
4-methyl-morpholine; ammonia in tetrahydrofuran; ethyl acetate
参考文献
SmithKline Beecham Corporation
Patent: US5998470 A1, 1999 ;
US 5998470 A
反应条件
hexamethylphosphorous triamide dichloride; ammonia in dichloromethane
1) 30 min, -20 deg C, 2) 4 h, r.t.;
参考文献
Appel, Rolf; Hiester, Ernst
Chemische Berichte, 1983 , vol. 116, # 5 p. 2037 - 2040
反应条件
1: EDCI, HOBt, NMM
2: acetic acid / 0.33 h / 65 °C
3: H2 / Pd/C
View Scheme
参考文献
Chen, Jian Jeffrey; Zhang, Yiping; Hammond, Scott; Dewdney, Nolan; Ho, Teresa; Lin, Xiaohong; Browner, Michelle F.; Castelhano, Arlindo L.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 13 p. 1601 - 1606
反应条件
sodium carbonate in N,N-dimethyl-formamide
T=20°C; Inert atmosphere;
参考文献
Xu, Zhigang; DiCesare, John C.; Baures, Paul W.
Journal of Combinatorial Chemistry, 2010 , vol. 12, # 2 p. 248 - 254
反应条件
boron trifluoride diethyl etherate
Heating;
参考文献
Virlouvet, Mickael; Goesmann, Helmut; Feldmann, Claus; Podlech, Joachim
Monatshefte fur Chemie, 2010 , vol. 141, # 2 p. 177 - 198
反应条件
4-methyl-morpholine; isobutyl chloroformate in tetrahydrofuran
T=20°C;
参考文献
Deska, Jan; Kazmaier, Uli
Chemistry - A European Journal, 2007 , vol. 13, # 21 p. 6204 - 6211
反应条件
(i) ClCO2Et, Et3N, THF, (ii) /BRN= 1963940/, (iii) H2, Pd, MeOH; Multistep reaction;
参考文献
Feltkamp; Pfrommer
Die Pharmazie, 1965 , vol. 20, # 5 p. 312 - 314
