N-苄氧羰基-L-亮氨酸合成路线 （共 125 条）
参考文献
Iselin et al.
Helvetica Chimica Acta, 1957 , vol. 40, p. 373,385
反应条件
pyridine T=40°C; 1.5 h;
参考文献
Oyamada, Hidekazu; Saito, Takashi; Inaba, Shinsaku; Ueki, Masaaki
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 4 p. 1422 - 1424
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide
Esterification;
参考文献
Ghosh, Arun K.; Liu, Chunfeng
Chemical Communications, 1999 , # 17 p. 1743 - 1744
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide
1) CH2Cl2, 4 deg C, 15 min, 2) DMF, 35 min; Yield given. Multistep reaction;
参考文献
Chadha, N. K.; Batcho, A. D.; Tang, P. C.; Courtney, L. F.; Cook, C. M.; et al.
Journal of Organic Chemistry, 1991 , vol. 56, # 15 p. 4714 - 4718
反应条件
1: 57 percent / DCC / CH2Cl2 / 10 h / Ambient temperature
2: 100 percent / Jones' reagent
View Scheme
参考文献
Grassmann; Wuensch
Chemische Berichte, 1958 , vol. 91, p. 449,453
反应条件
(i) ClCO2Et, Et3N, acetone, (ii) /BRN= 635782/, aq. NaOH; Multistep reaction;
参考文献
Beecham,A.F.
Australian Journal of Chemistry, 1963 , vol. 16, p. 160 - 164
反应条件
1: NMM
2: NMM
3: H2 / Pd/C
4: NMM
5: H2 / Pd/C
6: NMM
7: H2 / Pd/C
8: NMM
9: H2 / Pd/C
10: NMM
11: H2 / Pd/C
12: NMM
13: H2 / Pd/C
15: LiBH3 / tetrahydrofuran
View Scheme
参考文献
Toniolo; Crisma; Formaggio; Peggion; Monaco; Goulard; Rebuffat; Bodo
Journal of the American Chemical Society, 1996 , vol. 118, # 21 p. 4952 - 4958
反应条件
1: diethyl ether; phosphorus (V)-chloride / anschliessend Behandeln mit D-Phenylalanin-aethylester in Aethylacetat unter Zusatz von wss. Kaliumhydrogencarbonat-Loesung
2: aq. NaOH solution; dioxane / Hydrierung des Reaktionsprodukts an Palladium in wss.-methanol. Essigsaeure
View Scheme
参考文献
Synge
Biochemical Journal, 1948 , vol. 42, p. 99,101
反应条件
1: N-[(benzyloxy)carbonyl]-L-leucine With 1,1'-carbonyldioxydi[2(1H)-pyridone] in dichloromethane
T=20°C;
2: glycine ethyl ester hydrochloric acid With triethylamine in dichloromethane
T=-18°C;
参考文献
Shiina, Isamu; Kawakita, Yo-Ichi
Tetrahedron Letters, 2003 , vol. 44, # 9 p. 1951 - 1955
反应条件
2-N-methylamino-1,3,2-dioxaphospholane in acetonitrile
T=30°C; 20 h;
参考文献
Kawanobe, Wataru; Yamaguchi, Kazuo; Nakahama, Seiichi; Yamazaki, Noboru
Chemistry Letters, 1982 , p. 825 - 828
