5-氯-2-肼基-1,3-苯并噻唑合成路线 （共 7 条）
反应条件
hydrazine hydrate in ethanol T=100°C; 3 h; Inert atmosphere;
参考文献
COMPOUND HANDLING B.V.; STICHTING KATHOLIEKE UNIVERSITEIT; HOOIJ, VAN, Onno; SCHALKEN, Jacobus Antonius; VIËTOR, Hendrik Engelbertus; PIET, Dennis Patrick; MAAS, Petrus Emmanuel Marie; TIJHUIS, Johann Heinrich; DEERENBERG, Sirik; SPRENKELS, Nanda Elisabeth; TANG, Siu Ha
Patent: WO2013/131931 A1, 2013 ;
Location in patent: Page/Page column 30 ;
反应条件
sulfuric acid; hydrazine hydrate in ethylene glycol 4 h; Reflux;
参考文献
Ouyang, Liang; Huang, Yuhui; Zhao, Yuwei; He, Gu; Xie, Yongmei; Liu, Jie; He, Jun; Liu, Bo; Wei, Yuquan
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3044 - 3049
反应条件
hydrazine hydrate in ethanol; water 3 h; Reflux;
参考文献
Stella, Alessandro; Segers, Kenneth; De Jonghe, Steven; Vanderhoydonck, Bart; Rozenski, Jef; Anne, Jozef; Herdewijn, Piet
Chemistry and Biodiversity, 2011 , vol. 8, # 2 p. 253 - 265
反应条件
1: sodium hydroxide / 1 h / 20 °C 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 20 °C 3: hydrazine hydrate / ethanol; water / 3 h / Reflux View Scheme
参考文献
COMPOUND HANDLING B.V.; STICHTING KATHOLIEKE UNIVERSITEIT; HOOIJ, VAN, Onno; SCHALKEN, Jacobus Antonius; VIËTOR, Hendrik Engelbertus; PIET, Dennis Patrick; MAAS, Petrus Emmanuel Marie; TIJHUIS, Johann Heinrich; DEERENBERG, Sirik; SPRENKELS, Nanda Elisabeth; TANG, Siu Ha
Patent: WO2013/131931 A1, 2013 ;
反应条件
1.1: bromine; acetic acid / 7 h / 0 - 20 °C 1.2: pH 11 2.1: hydrazine hydrate; sulfuric acid / ethylene glycol / 4 h / Reflux View Scheme
参考文献
Ouyang, Liang; Huang, Yuhui; Zhao, Yuwei; He, Gu; Xie, Yongmei; Liu, Jie; He, Jun; Liu, Bo; Wei, Yuquan
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3044 - 3049
反应条件
1: potassium hydroxide / ethanol; water / Reflux 2: sodium hydroxide / 1 h / 20 °C 3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 20 °C 4: hydrazine hydrate / ethanol; water / 3 h / Reflux View Scheme
参考文献
Stella, Alessandro; Segers, Kenneth; De Jonghe, Steven; Vanderhoydonck, Bart; Rozenski, Jef; Anne, Jozef; Herdewijn, Piet
Chemistry and Biodiversity, 2011 , vol. 8, # 2 p. 253 - 265
反应条件
thionyl chloride T=50°C; 2 h;
参考文献
Ouyang, Liang; Huang, Yuhui; Zhao, Yuwei; He, Gu; Xie, Yongmei; Liu, Jie; He, Jun; Liu, Bo; Wei, Yuquan
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3044 - 3049
