diisopropylamine in DMF (N,N-dimethyl-formamide) T=40°C; 4.5 h;

triethylamine in acetonitrile T=25°C; 0.5 h;

1.1: acetic acid; dihydrogen peroxide; sulfuric acid / 2 h / 0 - 70 °C 2.1: acetic acid; hydrogen bromide / 0.08 h / 20 °C 2.2: 2.5 h / 25 - 58 °C 3.1: N,N-dimethyl-formamide View Scheme

1.1: acetic acid; hydrogen bromide / 0.08 h / 20 °C 1.2: 2.5 h / 25 - 58 °C 2.1: N,N-dimethyl-formamide View Scheme

1.1: AlCl3, aluminium chloride / chloroform / 1.5 h / -5 - 5 °C / |Cooling with ice 2.1: acetic acid; dihydrogen peroxide; sulfuric acid / 2 h / 0 - 70 °C 3.1: acetic acid; hydrogen bromide / 0.08 h / 20 °C 3.2: 2.5 h / 25 - 58 °C 4.1: N,N-dimethyl-formamide View Scheme

1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile T=0°C; 0.5 h;