4-甲基邻苯二甲酸二甲酯合成路线 （共 19 条）
反应条件
acetyl chloride
T=0 - 20°C;
参考文献
Nudelman, Ayelet; Bechor, Yosi; Falb, Eliezer; Fischer, Bilha; Wexler, Barry A.; Nudelman, Abraham
Synthetic Communications, 1998 , vol. 28, # 3 p. 471 - 474
反应条件
sulfuric acid
24 h; Heating / reflux;
参考文献
Jacobsen, Eric Jon; Myers, Jason K.; Walker, Daniel Patrick; Wishka, Donn G.; Reitz, Steven Charles; Piotrowski, David W.; Acker, Brad A.; Groppi JR., Vincent E.
Patent: US2003/236270 A1, 2003 ;
Location in patent: Page 43 ;
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in methanol
T=20°C; 3.5 h;
参考文献
Kureha Chemical Industry Co., Ltd.
Patent: EP1550657 A1, 2005 ;
Location in patent: Page/Page column 119 ;
反应条件
sulfuric acid in methanol
Heating / reflux;
参考文献
Pfizer Inc.
Patent: WO2003/106446 A1, 2003 ;
Location in patent: Page 30 ;
WO 03/106446 A1
反应条件
in benzene
T=55°C; 20 h;
参考文献
Kurita, Jyoji; Kakusawa, Naoki; Tsuchiya, Takashi
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 12 p. 4706 - 4710
反应条件
in benzene
T=70°C; 50 h;
参考文献
Casey, Charles P.; Ha, Yunkyoung; Powell, Douglas R.
Journal of Organometallic Chemistry, 1994 , vol. 472, # 1.2 p. 185 - 194
反应条件
in benzene
T=55 - 60°C; 168 h;
参考文献
Kurita, Jyoji; Kakusawa, Naoki; Tsuchiya, Takashi
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 12 p. 4706 - 4710
反应条件
in neat (no solvent)
15 h; Ambient temperature; Further byproducts given;
参考文献
Noland, Wayland E.; Lee, Chang Kiu
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4573 - 4582
反应条件
in benzene
T=40°C; 240 h;
参考文献
Kurita, Jyoji; Kakusawa, Naoki; Tsuchiya, Takashi
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 12 p. 4706 - 4710
反应条件
in neat (no solvent)
15 h; Ambient temperature; Further byproducts given;
参考文献
Noland, Wayland E.; Lee, Chang Kiu
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4573 - 4582
