2-溴-4'-氰基苯乙酮合成路线 （共 39 条）
参考文献
Kallmayer, Hans-Joerg; Wagner, Eugen
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 4 p. 315 - 323
反应条件
bromine in chloroform T=0°C; 2 h;
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 12 p. 4042 - 4056
反应条件
water; silver fluoride; trifluoroacetic acid T=40°C; 6 h; Green chemistry;
参考文献
Chen, Zheng-Wang; Ye, Dong-Nai; Ye, Min; Zhou, Zhong-Gao; Li, Shen-Huan; Liu, Liang-Xian
Tetrahedron Letters, 2014 , vol. 55, # 7 p. 1373 - 1375
反应条件
hydrogen bromide; oxygen in water; ethyl acetate T=20°C; 24 h; Irradiation;
参考文献
Tada, Norihiro; Ban, Kazunori; Hirashima, Shin-Ichi; Miura, Tsuyoshi; Itoh, Akichika
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 20 p. 4701 - 4704
反应条件
Oxonereg;; NH4Br 16 h; Reflux; regioselective reaction;
参考文献
Tetrahedron Letters, , vol. 53, # 2 p. 191 - 195
反应条件
oxygen T=10°C; 2 h; Irradiation;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 56, # 5 p. 1490 - 1496
参考文献
Dr. Karl Thomae GmbH
Patent: US4716169 A1, 1987 ;
反应条件
sodium hydrogencarbonate in ethanol 20 h; Heating / reflux;
参考文献
WO2007/28083 A2, ;
Page/Page column 132-133 ;
WO 2007/028083 A2
反应条件
1: sodium tetrahydroborate / methanol / 0 - 20 °C 2: potassium carbonate / methanol 3: C72H98Co2N4O8; hexafluoroisopropyl alcohol; benzoic acid fluoride; DBN; 2,2,2-trimethylacetic acid / decane; tert-butyl methyl ether / 2 h / 24 °C View Scheme
参考文献
Kalow, Julia A.; Doyle, Abigail G.
Journal of the American Chemical Society, 2011 , vol. 133, # 40 p. 16001 - 16012
反应条件
water in dimethyl sulfoxide T=20°C; 24 h;
参考文献
MITSUBISHI PHARMA CORPORATION; SANOFI-SYNTHELABO
Patent: WO2004/85408 A1, 2004 ;
Location in patent: Page 285 ;
WO 2004/085408 A1
