1,2,3-三氯-5-硝基苯合成路线 （共 17 条）
反应条件
1: cyanoacetic acid ethyl ester With sodium hydride in dimethyl sulfoxide
T=20°C; 0.5 h;
2: 1,2,3-trichloro-5-nitrobenzene in dimethyl sulfoxide
16 h;
参考文献
ADDEX PHARMA SA
Patent: WO2008/117175 A2, 2008 ;
Location in patent: Page/Page column 147-148 ;
WO 2008/117175 A2
反应条件
(i) KOH, DMSO, benzene, (ii) /BRN= 2505480/, DMF; Multistep reaction;
参考文献
Bayer
Patent: DE2509037 , 1976 ;
Chem.Abstr., 1976 , vol. 85, # 192761
反应条件
1: (i) KOH, DMSO, benzene, (ii) /BRN= 2505480/, DMF
2: SnCl2*2H2O, aq. HCl / dioxane
View Scheme
参考文献
Bayer
Patent: DE2509037 , 1976 ;
Chem.Abstr., 1976 , vol. 85, # 192761
反应条件
1: Sn; HCl
2: glacial acetic acid; chlorine
View Scheme
参考文献
Zincke; Schaum
Chemische Berichte, 1894 , vol. 27, p. 548
反应条件
(i) KOtBu, DMSO, (ii) /BRN= 2505480/, DMF; Multistep reaction;
参考文献
Ciba-Geigy
Patent: US5135953 A1, 1992 ;
反应条件
potassium carbonate in ethyl acetate; N,N-dimethyl-formamide
参考文献
Union Carbide Corporation
Patent: US4426385 A1, 1984 ;
反应条件
1: (i) KOtBu, DMSO, (ii) /BRN= 2505480/, DMF
2: SnCl2*2H2O, aq. HCl
View Scheme
参考文献
Bayer
Patent: DE2509037 , 1976 ;
Chem.Abstr., 1976 , vol. 85, # 192761
