1,2,3-三氯-5-硝基苯合成路线 （共 17 条）
反应条件
Cu2Cl2; hydrogenchloride; sulfuric acid in acetic acid 1 h;
参考文献
Miller; Mylari; Howes Jr.; Figdor; Lynch; Koch
Journal of Medicinal Chemistry, 1980 , vol. 23, # 10 p. 1083 - 1087
反应条件
nitric acid T=35°C; 1 h; Yields of byproduct given;
参考文献
Trinka; Berecz; Reiter
Journal fur Praktische Chemie - Chemiker - Zeitung, 1996 , vol. 338, # 7 p. 679 - 680
反应条件
in chloroform Irradiationother solvents; also in deaerated solutions and in presence of sensitizer; Product distribution;
参考文献
Photochemistry and Photobiology, , vol. 67, # 5 p. 532 - 537
反应条件
bei der Chlorierung;
参考文献
Journal of the Chemical Society, , vol. 87, p. 324
反应条件
potassium fluoride; N,N-dimethyl-formamide T=150°C;
参考文献
Basters,J.
Recueil des Travaux Chimiques des Pays-Bas, 1972 , vol. 91, p. 50 - 64
反应条件
1: dimethylformamide; potassium fluoride / 150 °C 2: SnCl2; aqueous HCl View Scheme
参考文献
Finger et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 94,95, 97
反应条件
in diethylene glycol
参考文献
Wyeth
Patent: EP1137645 B1, 2004 ;
Location in patent: Page 28 ;
反应条件
2,3-dimethylbutane-2,3-diol; [MoO2Cl2(dmf)2] in toluene T=150°C; 0.5 h; Microwave irradiation; chemoselective reaction;
参考文献
Garcia, Nuria; Garcia-Garcia, Patricia; Fernandez-Rodriguez, Manuel A.; Rubio, Ruben; Pedrosa, Maria R.; Arnaiz, Francisco J.; Sanz, Roberto
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 2-3 p. 321 - 327
反应条件
1: caesium carbonate / N,N-dimethyl-formamide / 25 - 70 °C 2: SnCl2*H2O / ethyl acetate / |Reflux 3: pyridine / dichloromethane / 25 - 60 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 4 p. 979 - 992
参考文献
Holleman; van Haeften
Recueil des Travaux Chimiques des Pays-Bas, 1921 , vol. 40, p. 74
