1: 2-methyl-3-nitropyridine With selenium(IV) oxide in 1,4-dioxane 48 h; Heating / reflux; 2: methanol

1.1: 86 percent / triphenylphosphine / Pd(PPh3)4 / toluene / 2 h / Heating 2.1: O3 / methanol / 0.25 h / -78 °C 2.2: Me2S / -78 - 20 °C View Scheme

1: 2-ethenyl-3-nitropyridine With ozone in methanol T=-78°C; ozonolysis; 0.25 h; 2: methanol With dimethylsulfide T=-78 - 20°C; Reduction; acetalation; Title compound not separated from byproducts;

1: (E)-3-(3-Nitro-pyridin-2-yl)-acrylic acid methyl ester With ozone in methanol ozonolysis; 2: methanol With dimethylsulfide Reduction; acetalation; Title compound not separated from byproducts;