2-(6-氯己氧基)四氢-2H-吡喃合成路线 （共 23 条）
反应条件
1: 1.) 2M BuLi / 1.) hexane, HMPT, 0 deg C, 30 min, 2.)THF, r. t., 12 h
2: p-TsOH / methanol / 2 h / Heating
View Scheme
参考文献
Rossi, Renzo; Carpita, Adriano; Gaudenzi, Loretta; Quirici, Maria Grazia
Gazzetta Chimica Italiana, 1980 , vol. 110, # 4 p. 237 - 246
反应条件
1.1: 98 percent / dimethylsulfoxide / 3 h / 20 °C
2.1: zirconocene chloride hydride / benzene / 6 h / 20 °C
2.2: 71 percent / I2 / benzene
3.1: Pd(PPh3)4 / benzene / 0.25 h / 20 °C
3.2: 70 percent / benzene / 20 °C
4.1: 80 percent / PPTs / methanol / 24 h / 20 °C
View Scheme
参考文献
Rossi, Renzo; Carpita, Adriano; Gaudenzi, Loretta; Quirici, Maria Grazia
Gazzetta Chimica Italiana, 1980 , vol. 110, # 4 p. 237 - 246
反应条件
1: 1.) 2M BuLi / 1.) hexane, HMPT, 0 deg C, 30 min, 2.)THF, r. t., 12 h
2: p-TsOH / methanol / 2 h / Heating
3: 95 percent / H2, quinoline / Lindlar catalyst / pentane / 1 h / -10 °C
4: 95 percent / pyridine / diethyl ether
View Scheme
参考文献
Rossi, Renzo; Carpita, Adriano; Gaudenzi, Loretta; Quirici, Maria Grazia
Gazzetta Chimica Italiana, 1980 , vol. 110, # 4 p. 237 - 246
反应条件
1: 1.) Mg, 2.) Li2CuCl4 / 1.) THF, 2.) THF, 0 deg C, 2 h
2: 1.) NH3, Li / 2.) DMSO, 45 min
View Scheme
参考文献
Michelot, Didier
Synthesis, 1983 , # 2 p. 130 - 134
反应条件
sodium iodide in acetone
72 h; Heating;
参考文献
Descoteaux, Caroline; Leblanc, Valerie; Belanger, Geoffroy; Parent, Sophie; Asselin, Eric; Berube, Gervais
Steroids, 2008 , vol. 73, # 11 p. 1077 - 1089
反应条件
magnesium
1.) THF, reflux, 1.5 h, 2.) reflux, 1 h.; Yield given. Multistep reaction;
参考文献
Barbry, Didier; Hasiak, Bruno
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # l p. 1734 - 1744
反应条件
ethylene dibromide in tetrahydrofuran
2 h; Inert atmosphereReflux;
参考文献
MARTEK BIOSCIENCES CORPORATION; RAMAN, Krishna; TARWADE, Vinod; SALEM, Norman, Jr.
Patent: WO2011/53892 A1, 2011 ;
Location in patent: Page/Page column 53 ;
反应条件
magnesium anthracene * 3 THF
1.) toluene, 90 deg C, 20 min, 2.) r.t., 12 h; Yield given. Multistep reaction;
参考文献
Bartmann, Ekkehard; Bogdanovic, Borislav; Janke, Nikolaus; Liao, Shijan; Schlichte, Klaus; et al.
Chemische Berichte, 1990 , vol. 123, # 7 p. 1517 - 1528
反应条件
1: 1.) 2M BuLi / 1.) hexane, HMPT, 0 deg C, 30 min, 2.)THF, r. t., 12 h
2: p-TsOH / methanol / 2 h / Heating
View Scheme
参考文献
Rossi, Renzo; Carpita, Adriano; Gaudenzi, Loretta; Quirici, Maria Grazia
Gazzetta Chimica Italiana, 1980 , vol. 110, # 4 p. 237 - 246
反应条件
1.1: 98 percent / dimethylsulfoxide / 3 h / 20 °C
2.1: zirconocene chloride hydride / benzene / 6 h / 20 °C
2.2: 71 percent / I2 / benzene
3.1: Pd(PPh3)4 / benzene / 0.25 h / 20 °C
3.2: 70 percent / benzene / 20 °C
4.1: 80 percent / PPTs / methanol / 24 h / 20 °C
View Scheme
参考文献
Yen, Yao-Pin; Chen, Pao-Hsing
Journal of the Chinese Chemical Society, 1999 , vol. 46, # 1 p. 87 - 90
