2-(5-甲氧基-1H-吲哚-3-基)-N-甲基乙胺合成路线 （共 14 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 5 h; Heating / reflux;
参考文献
FAUST PHARMACEUTICALS
Patent: WO2004/85392 A1, 2004 ;
Location in patent: Page 38 ;
反应条件
sodium hydroxide in methanol Heating;
参考文献
Somei; Yamada; Kurauchi; Nagahama; Hasegawa; Teranishi; Sato; Kaneko
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 1 p. 87 - 96
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1 h; Heating;
参考文献
Somei; Teranishi; Yamada
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 9 p. 1159 - 1165
反应条件
1: 85 percent / tert-butylcatechol / xylene / 3 h / Heating 2: H2 / 10 percent Pd/C / ethanol / 12 h / 2585.7 Torr 3: K2CO3 / H2O; toluene / 15 h / Ambient temperature 4: lithium aluminum hydride / tetrahydrofuran / 0.5 h / Heating View Scheme
参考文献
Repke, David B.; Grotjahn, Douglas B.; Shulgin, Alexander T.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 7 p. 892 - 896
反应条件
1: H2 / 10 percent Pd/C / ethanol / 12 h / 2585.7 Torr 2: K2CO3 / H2O; toluene / 15 h / Ambient temperature 3: lithium aluminum hydride / tetrahydrofuran / 0.5 h / Heating View Scheme
参考文献
Repke, David B.; Grotjahn, Douglas B.; Shulgin, Alexander T.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 7 p. 892 - 896
反应条件
1: K2CO3 / H2O; toluene / 15 h / Ambient temperature 2: lithium aluminum hydride / tetrahydrofuran / 0.5 h / Heating View Scheme
参考文献
Wilkinson
Journal of the Chemical Society, 1958 , p. 2079
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 0.5 h; Heating;
参考文献
Repke, David B.; Grotjahn, Douglas B.; Shulgin, Alexander T.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 7 p. 892 - 896
反应条件
1: 99 percent / Et3N / CHCl3 / 23 h / 20 °C 2: 95 percent / Et3SiH; TFA / 4 h / 70 °C 3: 76 percent / Na2WO4*2H2O; H2O2 / H2O; methanol / 0.67 h / 0 - 20 °C 4: 48 percent / 5 percent H2SO4 / 24 h / Heating 5: 93 percent / 40 percent aq. NaOH / methanol / 16 h / Heating View Scheme
参考文献
Somei, Masanori; Yamada, Fumio; Morikawa, Harunobu
Heterocycles, 1997 , vol. 46, p. 91 - 94
反应条件
1: 94 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating 2: 99 percent / Et3N / CHCl3 / 23 h / 20 °C 3: 95 percent / Et3SiH; TFA / 4 h / 70 °C 4: 76 percent / Na2WO4*2H2O; H2O2 / H2O; methanol / 0.67 h / 0 - 20 °C 5: 48 percent / 5 percent H2SO4 / 24 h / Heating 6: 93 percent / 40 percent aq. NaOH / methanol / 16 h / Heating View Scheme
参考文献
Somei, Masanori; Yamada, Fumio; Morikawa, Harunobu
Heterocycles, 1997 , vol. 46, p. 91 - 94
反应条件
1: 95 percent / Et3SiH; TFA / 4 h / 70 °C 2: 76 percent / Na2WO4*2H2O; H2O2 / H2O; methanol / 0.67 h / 0 - 20 °C 3: 48 percent / 5 percent H2SO4 / 24 h / Heating 4: 93 percent / 40 percent aq. NaOH / methanol / 16 h / Heating View Scheme
参考文献
Somei, Masanori; Yamada, Fumio; Morikawa, Harunobu
Heterocycles, 1997 , vol. 46, p. 91 - 94
