1: imidazole / dimethylformamide / 1 h / Ambient temperature 2: 1.) n-BuLi / 1.) THF, hexane, -20 deg C, 1 h, 2.) THF, hexane, RT, 1 h 3: 1.) LiCl, Na2CO3, Pd(OAc)2, 2.) KF, BnEt3NCl / 1.) DMF, 100 deg C, 3 h, 2.) CH3CN, reflux, 4 h View Scheme

1: 1.) n-BuLi / 1.) THF, hexane, -20 deg C, 1 h, 2.) THF, hexane, RT, 1 h 2: 1.) LiCl, Na2CO3, Pd(OAc)2, 2.) KF, BnEt3NCl / 1.) DMF, 100 deg C, 3 h, 2.) CH3CN, reflux, 4 h View Scheme

palladium diacetate; potassium fluoride; N-benzyl-N,N,N-triethylammonium chloride; sodium carbonate; lithium chloride 1.) DMF, 100 deg C, 3 h, 2.) CH3CN, reflux, 4 h; Yield given. Yields of byproduct given;