1: (Z)-2-(2-aminothiazol-4-yl)-2-(triphenylmethoxyimino)acetic acid With tributyl-amine; 1,4-diaza-bicyclo[2.2.2]octane in dichloromethane T=20 - 30°C; 0.333333 h; Inert atmosphere; 2: O,O-diethyl chlorothiophosphate in dichloromethane T=2°C; 0.5 h;

1.1: boron trifluoride diethyl etherate / acetic acid / ethyl acetate; water / 25.5 h / -5 - 45 °C / Inert atmosphere 2.1: potassium hydroxide; water / ethanol / 20 - 30 °C / Reflux 2.2: pH 4 - 5 3.1: tributyl-amine / 1,4-diaza-bicyclo[2.2.2]octane / dichloromethane / 0.33 h / 20 - 30 °C / Inert atmosphere 3.2: 0.5 h / 2 °C View Scheme

1.1: boron trifluoride diethyl etherate / acetic acid / ethyl acetate; water / 25.5 h / -5 - 45 °C / Inert atmosphere 2.1: potassium hydroxide; water / ethanol / 20 - 30 °C / Reflux 2.2: pH 4 - 5 3.1: tributyl-amine / 1,4-diaza-bicyclo[2.2.2]octane / dichloromethane / 0.33 h / 20 - 30 °C / Inert atmosphere 3.2: 0.5 h / 2 °C View Scheme