(3S,4r)-1-boc-3-羟基甲基-4-(4-氟苯基)-哌啶合成路线 （共 32 条）
反应条件
1: MeONa / methanol / 1 h / 0 °C
2: 64 percent / KOH / toluene / 24 h / Heating
3: Na2CO3 / CH2Cl2; H2O / 1 h / 0 °C
View Scheme
参考文献
De Gonzalo; Brieva; Sanchez; Bayod; Gotor
Journal of Organic Chemistry, 2001 , vol. 66, # 26 p. 8947 - 8953
反应条件
1.1: NaOMe / toluene / 0.5 h / 70 - 80 °C
2.1: LiAlH4 / toluene; tetrahydrofuran / 2 h / 73 - 75 °C
2.2: via salt with L-o-chlorotartranilic acid/Celite
3.1: aq. NaOH / toluene / 2 h / 45 - 55 °C
View Scheme
参考文献
Sugi, Kiyoshi; Itaya, Nobushige; Katsura, Tadashi; Igi, Masami; Yamazaki, Shigeya; Ishibashi, Taro; Yamaoka, Teiji; Kawada, Yoshihiro; Tagami, Yayoi; Otsuki, Michiya; Ohshima, Takao
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 4 p. 529 - 536
