顺式-7-十二碳烯-1-醇合成路线 （共 41 条）
反应条件
quinoline; hydrogen; Lindlar's catalyst in pentane
T=-10°C; 1 h;
参考文献
Sun, Wei Yan; Zong, Qin; Gu, Rue Lin; Pan, Bai Chuan
Synthesis, 1998 , # 11 p. 1619 - 1622
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=50°C; Reduction; 1 h;
参考文献
Bykov; Butenko; Egupova; Finkelshtein
Russian Chemical Bulletin, 2000 , vol. 49, # 7 p. 1301 - 1304
反应条件
hydrogenchloride in methanol
T=4°C; 3 h;
参考文献
Binisti, Carine; Assogba, Leon; Touboul, Estera; Mounier, Carine; Huet, Jack; Ombetta, Jean-Edouard; Dong, Chang Zhi; Redeuilh, Catherine; Heymans, Francoise; Godfroid, Jean-Jacques
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 10 p. 809 - 828
反应条件
sodium hydroxide in ethanol
1 h; Heating;
参考文献
Brown, Herbert C.; Wang, Kung K.
Journal of Organic Chemistry, 1986 , vol. 51, # 24 p. 4514 - 4517
反应条件
1: H2; quinoline / 5 percent Pd/BaSO4 / hexane / 24 h / 40 °C / 1034.3 Torr
2: 92 percent / hydrogen chloride / methanol / 3 h / 4 °C
View Scheme
参考文献
Binisti, Carine; Assogba, Leon; Touboul, Estera; Mounier, Carine; Huet, Jack; Ombetta, Jean-Edouard; Dong, Chang Zhi; Redeuilh, Catherine; Heymans, Francoise; Godfroid, Jean-Jacques
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 10 p. 809 - 828
反应条件
1: 85 percent / lithium amide / liquid ammonia; tetrahydrofuran
2: H2; quinoline / 5 percent Pd/BaSO4 / hexane / 24 h / 40 °C / 1034.3 Torr
3: 92 percent / hydrogen chloride / methanol / 3 h / 4 °C
View Scheme
参考文献
Binisti, Carine; Assogba, Leon; Touboul, Estera; Mounier, Carine; Huet, Jack; Ombetta, Jean-Edouard; Dong, Chang Zhi; Redeuilh, Catherine; Heymans, Francoise; Godfroid, Jean-Jacques
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 10 p. 809 - 828
反应条件
1: 89 percent / conc. hydrochloric acid / diethyl ether / 14 h / 0 - 20 °C
2: 85 percent / lithium amide / liquid ammonia; tetrahydrofuran
3: H2; quinoline / 5 percent Pd/BaSO4 / hexane / 24 h / 40 °C / 1034.3 Torr
4: 92 percent / hydrogen chloride / methanol / 3 h / 4 °C
View Scheme
参考文献
Binisti, Carine; Assogba, Leon; Touboul, Estera; Mounier, Carine; Huet, Jack; Ombetta, Jean-Edouard; Dong, Chang Zhi; Redeuilh, Catherine; Heymans, Francoise; Godfroid, Jean-Jacques
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 10 p. 809 - 828
反应条件
1: 70 percent / hydrobromic acid / benzene; H2O / 72 h / Heating
2: 89 percent / conc. hydrochloric acid / diethyl ether / 14 h / 0 - 20 °C
3: 85 percent / lithium amide / liquid ammonia; tetrahydrofuran
4: H2; quinoline / 5 percent Pd/BaSO4 / hexane / 24 h / 40 °C / 1034.3 Torr
5: 92 percent / hydrogen chloride / methanol / 3 h / 4 °C
View Scheme
参考文献
Binisti, Carine; Assogba, Leon; Touboul, Estera; Mounier, Carine; Huet, Jack; Ombetta, Jean-Edouard; Dong, Chang Zhi; Redeuilh, Catherine; Heymans, Francoise; Godfroid, Jean-Jacques
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 10 p. 809 - 828
反应条件
1.1: 68.4 percent / MoCl5/SiO2; SnMe4 / toluene / 24 h / 20 °C / 19000 Torr
2.1: 90 percent / LiAlH4; Cp2ZrCl2 / tetrahydrofuran / 2 h
3.1: 9-BBN
3.2: t-BuOK
4.1: LiAlH4
View Scheme
参考文献
Bykov, Victor I.; Butenko, Tamara A.; Petrova, Elena B.; Finkelshtein, Eugene Sh.
Tetrahedron, 1999 , vol. 55, # 27 p. 8249 - 8252
反应条件
1: 1.) LiNH2, Fe(NO3)3 / 1.) NH3 (liq.), -50 deg C, 2 h, 2.) THF, NH3, -50 deg C, 2 h; overnight
2: 95 percent / H2 / Pd/BaSO4 / pyridine / 3 h
View Scheme
参考文献
Sun, Wei Yan; Zong, Qin; Gu, Rue Lin; Pan, Bai Chuan
Synthesis, 1998 , # 11 p. 1619 - 1622
